Review of mTOR and cellular metabolism as mutual determinants in cancer.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | Narrative Review |
| Model system | Review |
| Journal | Nature reviews. Cancer |
| Year | 2018 |
| Peer reviewed | Yes |
| Source | DOI 10.1038/s41568-018-0074-8 · PMID 30425336 |
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. Conversely, metabolic inputs, such as amino acids, activate mTOR. In this Review, we discuss how mTOR signalling rewires cancer cell metabolism and delineate how changes in metabolism, in turn, sustain mTOR signalling and tumorigenicity. Several drugs are being developed to perturb cancer cell metabolism. However, their efficacy as stand-alone therapies, similar to mTOR inhibitors, is limited. Here, we discuss how the interdependence of mTOR signalling and metabolism can be exploited for cancer therapy.
| Intervention | Not applicable (review) |
| Target | mTOR |
| Model | Review |
| Effect | Reviews the reciprocal (mutual) control between mTOR signalling and cellular metabolism in cancer |