mTOR signalling and cellular metabolism are mutual determinants in cancer

Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. Conversely, metabolic inputs, such as amino acids, activate mTOR. In this Review, we discuss how mTOR signalling rewires cancer cell metabolism and delineate how changes in metabolism, in turn, sustain mTOR signalling and tumorigenicity. Several drugs are being developed to perturb cancer cell metabolism.

Read the full abstract on PubMed →

Mossmann, D., et al. (2018). mTOR signalling and cellular metabolism are mutual determinants in cancer. Nature reviews. Cancer. https://doi.org/10.1038/s41568-018-0074-8

@article{MOS2018,
  author       = {Mossmann, D. and Hall, M. N. and others},
  title        = {{mTOR signalling and cellular metabolism are mutual determinants in cancer}},
  journal      = {Nature reviews. Cancer},
  year         = {2018},
  doi          = {10.1038/s41568-018-0074-8},
  note         = {PMID: 30425336},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MOS2018) [Data set]. https://mtor-atlas.org/study/MOS2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MOS2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MOS2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MOS2018/},
  doi          = {10.5281/zenodo.22059963}
}