mTOR signalling and cellular metabolism are mutual determinants in cancer

Mossmann D, Park S, Hall MN · 2018 · Nature reviews. Cancer · Atlas ID MOS2018

What this study shows

Review of mTOR and cellular metabolism as mutual determinants in cancer.

Abstract

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Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR, which is frequently activated in cancer, controls cell growth and metabolism. mTOR signalling regulates amino acid, glucose, nucleotide, fatty acid and lipid metabolism. Conversely, metabolic inputs, such as amino acids, activate mTOR. In this Review, we discuss how mTOR signalling rewires cancer cell metabolism and delineate how changes in metabolism, in turn, sustain mTOR signalling and tumorigenicity. Several drugs are being developed to perturb cancer cell metabolism.

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At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Cancer
Year	2018
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s41568-018-0074-8 · PMID 30425336

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTOR
Model	Review
Effect	Reviews the reciprocal (mutual) control between mTOR signalling and cellular metabolism in cancer

In the Atlas

Cite this paper

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Mossmann, D., Park, S., & Hall, M. N. (2018). mTOR signalling and cellular metabolism are mutual determinants in cancer. Nature reviews. Cancer. https://doi.org/10.1038/s41568-018-0074-8

@article{MOS2018,
  author       = {Mossmann, D. and Park, S. and Hall, M. N.},
  title        = {{mTOR signalling and cellular metabolism are mutual determinants in cancer}},
  journal      = {Nature reviews. Cancer},
  year         = {2018},
  doi          = {10.1038/s41568-018-0074-8},
  note         = {PMID: 30425336},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MOS2018) [Data set]. https://mtor-atlas.org/study/MOS2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MOS2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MOS2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MOS2018/},
  doi          = {10.5281/zenodo.22059963}
}

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