TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop. Rapamycin triggers a similar protective response in C.

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Robida-Stubbs, S., et al. (2012). TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell metabolism. https://doi.org/10.1016/j.cmet.2012.04.007

@article{ROB2012,
  author       = {Robida-Stubbs, S. and Blackwell, T. K. and others},
  title        = {{TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO}},
  journal      = {Cell metabolism},
  year         = {2012},
  doi          = {10.1016/j.cmet.2012.04.007},
  note         = {PMID: 22560223},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ROB2012) [Data set]. https://mtor-atlas.org/study/ROB2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROB2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROB2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROB2012/},
  doi          = {10.5281/zenodo.22059963}
}