TOR signaling in growth and metabolism

Wullschleger S, Loewith R, Hall MN · 2006 · Cell · Atlas ID WUL2006

What this study shows

Landmark review synthesizing TOR signalling in growth and metabolism across organisms.

Abstract

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The target of rapamycin (TOR) is a conserved Ser/Thr kinase that regulates cell growth and metabolism in response to environmental cues. Here, highlighting contributions from studies in model organisms, we review mammalian TOR complexes and the signaling branches they mediate. TOR is part of two distinct multiprotein complexes, TOR complex 1 (TORC1), which is sensitive to rapamycin, and TORC2, which is not.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Cell
Year	2006
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cell.2006.01.016 · PMID 16469695

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	TORC1 / TORC2
Model	Review
Effect	Reviews TOR complexes and the signaling branches they mediate in growth and metabolism

In the Atlas

Cite this paper

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Wullschleger, S., Loewith, R., & Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell. https://doi.org/10.1016/j.cell.2006.01.016

@article{WUL2006,
  author       = {Wullschleger, S. and Loewith, R. and Hall, M. N.},
  title        = {{TOR signaling in growth and metabolism}},
  journal      = {Cell},
  year         = {2006},
  doi          = {10.1016/j.cell.2006.01.016},
  note         = {PMID: 16469695},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WUL2006) [Data set]. https://mtor-atlas.org/study/WUL2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WUL2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WUL2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WUL2006/},
  doi          = {10.5281/zenodo.22059963}
}

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