Oliver's mTOR Atlas Evidence Platform
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Structure of mammalian AMPK and its regulation by ADP

Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, …, Gamblin SJ · 2011 · Nature · Atlas ID XIA2011

What this study shows

AMP binding to the gamma regulatory domain promotes phosphorylation of AMPK and protects it from dephosphorylation. ADP binding to one site also protects against dephosphorylation but does not activate allosterically. Crystal structure of an active AMPK complex.

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Purified mammalian AMPK; crystal structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemPurified mammalian AMPK; crystal structure
JournalNature
Year2011
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1038/nature09932 · PMID 21399626 · Free full text (PMC3078618)

In the Atlas

Links in the pathway map

Cite this paper

ShowHide 
Xiao, B., Sanders, M. J., Underwood, E., Heath, R., Mayer, F. V., Carmena, D., Jing, C., Walker, P. A., Eccleston, J. F., Haire, L. F., Saiu, P., Howell, S. A., Aasland, R., Martin, S. R., Carling, D., & Gamblin, S. J. (2011). Structure of mammalian AMPK and its regulation by ADP. Nature. https://doi.org/10.1038/nature09932

@article{XIA2011,
  author       = {Xiao, B. and Sanders, M. J. and Underwood, E. and Heath, R. and Mayer, F. V. and Carmena, D. and Jing, C. and Walker, P. A. and Eccleston, J. F. and Haire, L. F. and Saiu, P. and Howell, S. A. and Aasland, R. and Martin, S. R. and Carling, D. and Gamblin, S. J.},
  title        = {{Structure of mammalian AMPK and its regulation by ADP}},
  journal      = {Nature},
  year         = {2011},
  doi          = {10.1038/nature09932},
  note         = {PMID: 21399626},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record XIA2011) [Data set]. https://mtor-atlas.org/study/XIA2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_XIA2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record XIA2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/XIA2011/},
  doi          = {10.5281/zenodo.22059963}
}
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