Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R · 2019 · Science · Atlas ID LAW2019

What this study shows

Structure reveals the FLCN complex as a Rag-GTPase activation checkpoint gating mTORC1.

Abstract

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The tumor suppressor folliculin (FLCN) enables nutrient-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) protein kinase via its guanosine triphosphatase (GTPase) activating protein (GAP) activity toward the GTPase RagC. Concomitant with mTORC1 inactivation by starvation, FLCN relocalizes from the cytosol to lysosomes.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Structure; cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Structure; cells
Journal	Science
Year	2019
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/science.aax0364 · PMID 31672913 · Free full text (PMC6945816)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Structural/biochemical (FLCN complex)
Target	FLCN–FNIP2 / RagC / mTORC1
Model	Structure; cells
Effect	The lysosomal folliculin complex acts as a GAP for RagC, a checkpoint in nutrient-dependent mTORC1 activation

In the Atlas

Links in the pathway map

Supports FLCN / FNIP1/2 activates Rag GTPases

Cite this paper

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Lawrence, R. E., Fromm, S. A., Fu, Y., Yokom, A. L., Kim, D. J., Thelen, A. M., Young, L. N., Lim, C. Y., Samelson, A. J., Hurley, J. H., & Zoncu, R. (2019). Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science. https://doi.org/10.1126/science.aax0364

@article{LAW2019,
  author       = {Lawrence, R. E. and Fromm, S. A. and Fu, Y. and Yokom, A. L. and Kim, D. J. and Thelen, A. M. and Young, L. N. and Lim, C. Y. and Samelson, A. J. and Hurley, J. H. and Zoncu, R.},
  title        = {{Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex}},
  journal      = {Science},
  year         = {2019},
  doi          = {10.1126/science.aax0364},
  note         = {PMID: 31672913},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LAW2019) [Data set]. https://mtor-atlas.org/study/LAW2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LAW2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LAW2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LAW2019/},
  doi          = {10.5281/zenodo.22059963}
}

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