Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling.

Rauch B, Ujlaki G, Poliska S, Murahwa N, Kovacs P, Pettko-Szandtner A, Uray K, Bai P · 2026 · The FEBS journal · Atlas ID RAUCH2026

What this study shows

Deleting TNKS1 or TNKS2 slows adipocyte differentiation, with inhibited autophagy, AMPK activation and suppressed mTORC1; the TNKS2-knockout defect is rescued by NV-5138 or by LKB1 inhibition, and TNKS2 ADP-ribosylates LKB1 (cell line).

Cited on mTOR drugs in development: SPN-820

Abstract

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Although tankyrases (TNKSs) were originally described as enzymes safeguarding genome integrity, TNKSs are also associated with metabolism and are involved in the differentiation of multiple cell lineages including adipocytes. Here we aimed to understand the role of TNKSs specifically in adipocyte differentiation. We found that the deletion of TNKS1 or TNKS2 decreased the rate of adipocyte differentiation.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cell line (adipocytes)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Cell line (adipocytes)
Journal	The FEBS journal
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1111/febs.70676 · PMID 42563506

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	TNKS2 knockout / NV-5138 (autophagy activator)
Target	AMPK/mTORC1
Model	Cell line
Effect	Reduces adipocyte differentiation rate; AMPK activation suppresses mTORC1

In the Atlas

Cite this paper

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Rauch, B., Ujlaki, G., Poliska, S., Murahwa, N., Kovacs, P., Pettko-Szandtner, A., Uray, K., & Bai, P. (2026). Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling. The FEBS journal. https://doi.org/10.1111/febs.70676

@article{RAUCH2026,
  author       = {Rauch, B. and Ujlaki, G. and Poliska, S. and Murahwa, N. and Kovacs, P. and Pettko-Szandtner, A. and Uray, K. and Bai, P.},
  title        = {{Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling}},
  journal      = {The FEBS journal},
  year         = {2026},
  doi          = {10.1111/febs.70676},
  note         = {PMID: 42563506},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record RAUCH2026) [Data set]. https://mtor-atlas.org/study/RAUCH2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_RAUCH2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record RAUCH2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/RAUCH2026/},
  doi          = {10.5281/zenodo.22059963}
}

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