Oliver's mTOR Atlas Evidence Platform
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Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling.

Rauch B, Ujlaki G, Poliska S, Murahwa N, Kovacs P et al. · 2026 · The FEBS journal · Atlas ID RAUCH2026

What this study shows

Deletion of tankyrase-2 (TNKS2) impairs adipocyte differentiation through AMPK activation and mTORC1 suppression; pharmacological autophagy activation rescues the differentiation defect.

Abstract

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Although tankyrases (TNKSs) were originally described as enzymes safeguarding genome integrity, TNKSs are also associated with metabolism and are involved in the differentiation of multiple cell lineages including adipocytes. Here we aimed to understand the role of TNKSs specifically in adipocyte differentiation. We found that the deletion of TNKS1 or TNKS2 decreased the rate of adipocyte differentiation.

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At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cell line (adipocytes)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCell line (adipocytes)
JournalThe FEBS journal
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1111/febs.70676

Extracted findings

InterventionTNKS2 knockout / NV-5138 (autophagy activator)
TargetAMPK/mTORC1
ModelCell line
EffectReduces adipocyte differentiation rate; AMPK activation suppresses mTORC1

In the Atlas

Related topics

TNKS2 (Tankyrase-2)

Cite this paper

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Rauch, B., et al. (2026). Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling. The FEBS journal. https://doi.org/10.1111/febs.70676

@article{RAUCH2026,
  author       = {Rauch, B. and Ujlaki, G. and Poliska, S. and Murahwa, N. and Kovacs, P. and others},
  title        = {{Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling}},
  journal      = {The FEBS journal},
  year         = {2026},
  doi          = {10.1111/febs.70676},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record RAUCH2026) [Data set]. https://mtor-atlas.org/study/RAUCH2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_RAUCH2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record RAUCH2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/RAUCH2026/},
  doi          = {10.5281/zenodo.22059963}
}