PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains

Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G · 2008 · Proceedings of the National Academy of Sciences · Atlas ID SUZ2008

What this study shows

Both MA3 domains of PDCD4 bind the N-terminal domain of eIF4A and compete with eIF4G and RNA for it, which explains how PDCD4 blocks translation initiation.

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Structural and biophysical work on human proteins) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Structural and biophysical work on human proteins
Journal	Proceedings of the National Academy of Sciences
Year	2008
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1073/pnas.0712235105 · PMID 18296639 · Free full text (PMC2265113)

In the Atlas

Links in the pathway map

Supports PDCD4 inhibits Protein synthesis

Cite this paper

ShowHide

Suzuki, C., Garces, R. G., Edmonds, K. A., Hiller, S., Hyberts, S. G., Marintchev, A., & Wagner, G. (2008). PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0712235105

@article{SUZ2008,
  author       = {Suzuki, C. and Garces, R. G. and Edmonds, K. A. and Hiller, S. and Hyberts, S. G. and Marintchev, A. and Wagner, G.},
  title        = {{PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains}},
  journal      = {Proceedings of the National Academy of Sciences},
  year         = {2008},
  doi          = {10.1073/pnas.0712235105},
  note         = {PMID: 18296639},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SUZ2008) [Data set]. https://mtor-atlas.org/study/SUZ2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SUZ2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SUZ2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SUZ2008/},
  doi          = {10.5281/zenodo.22059963}
}

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