Genetics: influence of TOR kinase on lifespan in C. elegans
What this study shows
Silencing the single worm TOR gene roughly doubled C. elegans lifespan, showing the longevity role of TOR inhibition is conserved across an enormous evolutionary distance.
At a glance
| Evidence type | A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Caenorhabditis elegans (RNAi)); the code names the system studied -- animal work can be rigorous and still not be human data. |
| Study type | 4 - Animal Study |
| Model system | Caenorhabditis elegans (RNAi) |
| Journal | Nature |
| Year | 2003 |
| Peer reviewed | Yes |
| Record last updated | 2026-10-01 |
| Source | DOI 10.1038/426620a · PMID 14668850 |
Extracted findings
These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.
| Intervention | Genetic (RNAi of let-363/CeTOR) |
| Target | TOR (CeTOR) |
| Model | C. elegans |
| Effect | RNAi of C. elegans TOR roughly doubles adult lifespan, acting largely parallel to insulin/IGF-1-DAF-16 |
In the Atlas
Related topics
Links in the pathway map
- Supports mTORC1 inhibits Longevity
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