Genetics: influence of TOR kinase on lifespan in C. elegans

(Brief communication; no formal abstract in PubMed — editorial summary.) This report provides the first genetic evidence that the TOR kinase controls animal lifespan: RNAi inactivation of the Caenorhabditis elegans TOR ortholog (let-363/CeTOR) roughly doubles adult lifespan. The longevity effect operates largely in parallel to the insulin/IGF-1–DAF-16 pathway and is associated with a dauer-like shift in energy metabolism, establishing nutrient-sensing TOR signalling as an evolutionarily conserved regulator of ageing and laying the groundwork for later work on rapamycin and lifespan extension.

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Vellai, T., et al. (2003). Genetics: influence of TOR kinase on lifespan in C. elegans. Nature. https://doi.org/10.1038/426620a

@article{VEL2003,
  author       = {Vellai, T. and others},
  title        = {{Genetics: influence of TOR kinase on lifespan in C. elegans}},
  journal      = {Nature},
  year         = {2003},
  doi          = {10.1038/426620a},
  note         = {PMID: 14668850},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record VEL2003) [Data set]. https://mtor-atlas.org/study/VEL2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_VEL2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record VEL2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/VEL2003/},
  doi          = {10.5281/zenodo.22059963}
}