LINP1 suppresses radiation-induced cellular senescence in keratinocytes by modulating the mTOR-p53 axis

Liang X, Hou M, Liu Yaru, Yang Y, Zhang C, Zhang Z, Zhou L · 2026 · Molecular and Cellular Biochemistry · Atlas ID LIANG2026

What this study shows

LncRNA LINP1 binds the FAT domain of mTOR, reduces mTOR-p53 interaction and p53 Ser15 phosphorylation, thereby suppressing radiation-induced cellular senescence in keratinocytes and human skin.

Abstract

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LINP1 is a markedly upregulated lncRNA following ionizing radiation (IR). LINP1 promotes cell survival and limits radiation-induced DNA damage accumulation. Mechanistically, LINP1 attenuates radiation-induced cellular senescence through modulation of the mTOR-p53 signaling axis: LINP1 associates with the FAT domain of mTOR, attenuates the interaction between mTOR and p53, thereby reducing p53 Ser15 phosphorylation and downstream senescence-associated signaling.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Human keratinocytes; ex vivo human skin explants) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Human keratinocytes; ex vivo human skin explants
Journal	Molecular and Cellular Biochemistry
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1007/s11010-026-05682-z

Extracted findings

Intervention	LINP1 overexpression/knockdown; ionizing radiation
Target	mTOR FAT domain; mTOR-p53 interaction; p53 Ser15 phosphorylation; cellular senescence
Model	Human
Effect	LINP1 directly binds mTOR FAT domain to reduce mTOR-p53 interaction, decrease p53 activation, and suppress radiation-induced senescence

Cite this paper

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Liang, X., Hou, M., Liu Yaru, Yang, Y., Zhang, C., Zhang, Z., & Zhou, L. (2026). LINP1 suppresses radiation-induced cellular senescence in keratinocytes by modulating the mTOR-p53 axis. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-026-05682-z

@article{LIANG2026,
  author       = {Liang, X. and Hou, M. and Liu Yaru and Yang, Y. and Zhang, C. and Zhang, Z. and Zhou, L.},
  title        = {{LINP1 suppresses radiation-induced cellular senescence in keratinocytes by modulating the mTOR-p53 axis}},
  journal      = {Molecular and Cellular Biochemistry},
  year         = {2026},
  doi          = {10.1007/s11010-026-05682-z},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LIANG2026) [Data set]. https://mtor-atlas.org/study/LIANG2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LIANG2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LIANG2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LIANG2026/},
  doi          = {10.5281/zenodo.22059963}
}