Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis.

Yao J, Chen Yingfeng, Pan F, Zhang S · 2026 · Biological & Pharmaceutical Bulletin · Atlas ID YAO2026

What this study shows

Salvianolic acid B improved motor recovery, neuronal survival and angiogenesis after rat spinal cord injury in association with AKT/mTOR/HIF-1α activation; the effects were reversed by the AKT inhibitor capivasertib.

Abstract

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Spinal cord injury (SCI) is a devastating condition with limited treatment options. Salvianolic acid B (SalB), a natural compound from Salvia miltiorrhiza, shows therapeutic potential but its mechanisms in SCI remain unclear. This study combined network pharmacology, molecular docking and in vivo experiments using a rat SCI model, applying the AKT inhibitor capivasertib (AZD5363) for mechanistic verification. Network analysis identified 188 SalB-SCI common targets primarily in the AKT pathway, and molecular docking predicted strong binding between SalB and AKT1.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Rat (spinal cord injury model)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Rat (spinal cord injury model)
Journal	Biological & Pharmaceutical Bulletin
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1248/bpb.b26-00280 · PMID 42649073

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Salvianolic acid B; capivasertib (AZD5363) as AKT inhibitor control
Target	AKT/mTOR/HIF-1α; AKT1; angiogenesis
Model	Rat
Effect	Improved motor function, reduced tissue damage, enhanced neuronal survival and angiogenesis; abolished by AKT inhibition

In the Atlas

Cite this paper

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Yao, J., Chen Yingfeng, Pan, F., & Zhang, S. (2026). Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis. Biological & Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.b26-00280

@article{YAO2026,
  author       = {Yao, J. and Chen Yingfeng and Pan, F. and Zhang, S.},
  title        = {{Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis}},
  journal      = {Biological & Pharmaceutical Bulletin},
  year         = {2026},
  doi          = {10.1248/bpb.b26-00280},
  note         = {PMID: 42649073},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record YAO2026) [Data set]. https://mtor-atlas.org/study/YAO2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YAO2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YAO2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YAO2026/},
  doi          = {10.5281/zenodo.22059963}
}

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