Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis.

Spinal cord injury (SCI) is a devastating condition with limited treatment options. Salvianolic acid B (SalB), a natural compound from Salvia miltiorrhiza, shows therapeutic potential but its mechanisms in SCI remain unclear. This study combined network pharmacology, molecular docking and in vivo experiments using a rat SCI model, applying the AKT inhibitor capivasertib (AZD5363) for mechanistic verification. Network analysis identified 188 SalB-SCI common targets primarily in the AKT pathway, and molecular docking predicted strong binding between SalB and AKT1.

Read the full abstract →

Yao, J., Chen Yingfeng, Pan, F., & Zhang, S. (2026). Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis. Biological & Pharmaceutical Bulletin. https://doi.org/10.1248/bpb.b26-00280

@article{YAO2026,
  author       = {Yao, J. and Chen Yingfeng and Pan, F. and Zhang, S.},
  title        = {{Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis}},
  journal      = {Biological & Pharmaceutical Bulletin},
  year         = {2026},
  doi          = {10.1248/bpb.b26-00280},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record YAO2026) [Data set]. https://mtor-atlas.org/study/YAO2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YAO2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YAO2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YAO2026/},
  doi          = {10.5281/zenodo.22059963}
}