Oliver's mTOR Atlas Evidence Platform
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Rapamycin in Frail Older Subjects with Heart Failure with Preserved Ejection Fraction

Lane CM, Mill J, Ellingson P, James I, Borlaug BA, Olson TP, Bagwell MS, Lewis BR, Ingraham BS, Huxley S, Behfar A, Kirkland JL · 2026 · Mayo Clinic Proceedings · Atlas ID LAN2026

What this study shows

Trial of low-dose rapamycin in frail older adults with heart failure with preserved ejection fraction (HFpEF), from a Mayo Clinic/UW-Madison team including senolytics/mTOR-aging researchers Kirkland and Lamming; abstract not yet available (ahead-of-print).

Abstract

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[Abstract not yet available in PubMed - ahead-of-print, indexed 2026-09-18]

Read the full abstract on PubMed →

At a glance

Evidence type H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type2 - Human Clinical Trial
Model systemHuman (frail older adults with HFpEF)
JournalMayo Clinic Proceedings
Year2026
Peer reviewedYes
Record last updated2026-09-23
SourceDOI 10.1016/j.mayocp.2026.09.006 · PMID 42759606

Cite this paper

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Lane, C. M., Mill, J., Ellingson, P., James, I., Borlaug, B. A., Olson, T. P., Bagwell, M. S., Lewis, B. R., Ingraham, B. S., Huxley, S., Behfar, A., Kirkland, J. L., Lamming, D. W., Simcox, J. A., & Singh, M. (2026). Rapamycin in Frail Older Subjects with Heart Failure with Preserved Ejection Fraction. Mayo Clinic Proceedings. https://doi.org/10.1016/j.mayocp.2026.09.006

@article{LAN2026,
  author       = {Lane, C. M. and Mill, J. and Ellingson, P. and James, I. and Borlaug, B. A. and Olson, T. P. and Bagwell, M. S. and Lewis, B. R. and Ingraham, B. S. and Huxley, S. and Behfar, A. and Kirkland, J. L. and Lamming, D. W. and Simcox, J. A. and Singh, M.},
  title        = {{Rapamycin in Frail Older Subjects with Heart Failure with Preserved Ejection Fraction}},
  journal      = {Mayo Clinic Proceedings},
  year         = {2026},
  doi          = {10.1016/j.mayocp.2026.09.006},
  note         = {PMID: 42759606},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record LAN2026) [Data set]. https://mtor-atlas.org/study/LAN2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LAN2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LAN2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LAN2026/},
  doi          = {10.5281/zenodo.22059963}
}