Molecular logic of mTORC1 signalling as a metabolic rheostat

Valvezan AJ, Manning BD · 2019 · Nature metabolism · Atlas ID VAL2019

What this study shows

Review framing mTORC1 as a metabolic rheostat coupling growth signals to metabolism.

Abstract

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The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves as a key conduit between growth signals and the metabolic processes underlying cell growth. The activation state of mTORC1 is controlled by intracellular nutrients and energy, as well as exogenous hormones and growth factors, thereby integrating local and systemic growth signals. Here we discuss the molecular logic of the mTORC1 signalling network and its importance in coupling growth signals to the control of cellular metabolism.

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At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature metabolism
Year	2019
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s42255-019-0038-7 · PMID 32694720 · Free full text (PMC12569966)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1
Model	Review
Effect	Frames mTORC1 as a metabolic rheostat coupling growth signals to cellular metabolism

In the Atlas

Cite this paper

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Valvezan, A. J., & Manning, B. D. (2019). Molecular logic of mTORC1 signalling as a metabolic rheostat. Nature metabolism. https://doi.org/10.1038/s42255-019-0038-7

@article{VAL2019,
  author       = {Valvezan, A. J. and Manning, B. D.},
  title        = {{Molecular logic of mTORC1 signalling as a metabolic rheostat}},
  journal      = {Nature metabolism},
  year         = {2019},
  doi          = {10.1038/s42255-019-0038-7},
  note         = {PMID: 32694720},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record VAL2019) [Data set]. https://mtor-atlas.org/study/VAL2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_VAL2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record VAL2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/VAL2019/},
  doi          = {10.5281/zenodo.22059963}
}

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