Molecular logic of mTORC1 signalling as a metabolic rheostat

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves as a key conduit between growth signals and the metabolic processes underlying cell growth. The activation state of mTORC1 is controlled by intracellular nutrients and energy, as well as exogenous hormones and growth factors, thereby integrating local and systemic growth signals. Here we discuss the molecular logic of the mTORC1 signalling network and its importance in coupling growth signals to the control of cellular metabolism.

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Valvezan, A. J., et al. (2019). Molecular logic of mTORC1 signalling as a metabolic rheostat. Nature metabolism. https://doi.org/10.1038/s42255-019-0038-7

@article{VAL2019,
  author       = {Valvezan, A. J. and Manning, B. D. and others},
  title        = {{Molecular logic of mTORC1 signalling as a metabolic rheostat}},
  journal      = {Nature metabolism},
  year         = {2019},
  doi          = {10.1038/s42255-019-0038-7},
  note         = {PMID: 32694720},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record VAL2019) [Data set]. https://mtor-atlas.org/study/VAL2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_VAL2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record VAL2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/VAL2019/},
  doi          = {10.5281/zenodo.22059963}
}