Oliver's mTOR Atlas Evidence Platform
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D-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia.

Shim JH Lee JY Ahn BK Woo SW Han J Kim HS · 2026 · Molecular Therapy · Atlas ID SHIM2026

What this study shows

DLMEH, a D-leucine ester prodrug, binds Sestrin2 with leucine-like potency and improved pharmacokinetics, activating mTORC1 to restore muscle protein synthesis and muscle mass/function in a sarcopenia model — a mechanistic and pharmacological advance on the amino-acid-sensing (Sestrin2→mTORC1) axis.

At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse sarcopenia model); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemMouse sarcopenia model
JournalMolecular Therapy
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/j.ymthe.2026.09.007 · PMID 42723280

Cite this paper

ShowHide 
Shim JH
Lee JY
Ahn BK
Woo SW
Han J
Kim HS (2026). D-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia. Molecular Therapy. https://doi.org/10.1016/j.ymthe.2026.09.007

@article{SHIM2026,
  author       = {Shim JH
Lee JY
Ahn BK
Woo SW
Han J
Kim HS},
  title        = {{D-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia}},
  journal      = {Molecular Therapy},
  year         = {2026},
  doi          = {10.1016/j.ymthe.2026.09.007},
  note         = {PMID: 42723280},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record SHIM2026) [Data set]. https://mtor-atlas.org/study/SHIM2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SHIM2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SHIM2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SHIM2026/},
  doi          = {10.5281/zenodo.22059963}
}