5 scientists over 3 generations of training, 2010–2025.
The family starts with Aurelio A. Teleman, whose lab trained Constantinos Demetriades.
The lab with the most trainees here is Constantinos Demetriades's,
with 3 people in this tree.
5 of the 5 have a full profile in the Atlas. Positions and dates come from
the sources listed under each person and can lag behind job moves.
What the family's own labs work on
mTORC1 nutrient sensing 2
Lysosome & autophagy 1
Aging & lifespan 1
The tree
Read left to right: each line means "trained in this lab". Names with a profile are links.
Dashed rings mark people without a profile yet. Open it in the interactive map →
In the labShowed that when amino acids or growth factors run out, the Rag GTPases pull TSC2 to the lysosome, where it switches off Rheb and releases mTORC1 (Cell 2014).
Own labDemetriades Lab, European Research Institute for the Biology of Ageing (ERIBA), UMCG (Groningen, Netherlands). He studies where in the cell the mTOR switch is turned off when food runs out, and what that means for ageing.Spatial regulation of mTORC1 by amino acids and stress (TSC2, Rags, lysosomal and non-lysosomal mTORC1 pools) and its relevance to ageing.
In the labCo-authored the studies on the spatial split of mTORC1 by amino-acid source and on malonyl-CoA as a direct mTORC1 inhibitor.
Own labNüchel Lab, Center for Biochemistry, Medical Faculty, University of Cologne (Cologne, North Rhine-Westphalia, Germany). He studies how the cell's own metabolic by-products tune the mTOR growth switch.Metabolic regulation of mTORC1 signalling in his own junior group.
In the labShowed that the four Rag GTPase paralogues are not interchangeable: RagC/D decides which substrates mTORC1 picks, RagA/B sets the response to amino-acid withdrawal (Nat Cell Biol 2022).
Own labFrezza Lab, CECAD Cluster of Excellence, University of Cologne (Cologne, North Rhine-Westphalia, Germany). First author of the 'Rag dimer code' study showing that the four Rag GTPase paralogues are not interchangeable: RagC/D sets substrate choice and RagA/B sets the response to amino acid withdrawal.
PhD + postdoc, PhD 2017-2023, postdoc 2023-2025 (MPI for Biology of Ageing, Cologne)
In the labShowed that mTORC1 is split in space: a lysosomal pool and a cytoplasmic pool respond to different amino-acid sources and phosphorylate different substrates (Nat Cell Biol 2024).
Own labFernandes Group (Muscle Metabolism and Ageing), Max Planck Institute for Biology of Ageing (Cologne, North Rhine-Westphalia, Germany). She studies how muscle cells sense food through mTOR, and how that changes as we age.Nutrient signalling and mTORC1 in skeletal muscle metabolism and ageing.
How links are chosen: a link appears only when two independent sources agree, a PubMed
paper the trainee wrote with the mentor at the mentor's institution and a separate page naming the mentor.
More on the method.
