4 scientists over 3 generations of training, 1989–2015.
The family starts with Jack E. Dixon, whose lab trained Kun-Liang Guan.
The lab with the most trainees here is Kun-Liang Guan's,
with 2 people in this tree.
3 of the 4 have a full profile in the Atlas. Positions and dates come from
the sources listed under each person and can lag behind job moves.
What the family's own labs work on
mTORC1 nutrient sensing 2
Lysosome & autophagy 1
The tree
Read left to right: each line means "trained in this lab". Names with a profile are links.
Dashed rings mark people without a profile yet. Open it in the interactive map →
In the labShowed that protein-tyrosine phosphatases work through a cysteine-phosphate intermediate (Cys215).
Own labGuan Lab, Westlake University (Hangzhou, Zhejiang, China). He studies how a cell decides whether it has enough food and energy to grow, and the molecular switches that turn mTOR on or off.Nutrient and growth-factor control of mTORC1 (TSC2 regulation by Akt and AMPK, Rag GTPases, Arf1-dependent glutamine sensing) and Hippo-YAP signalling.
In the labShowed that leucine activates mTORC1 through the Rags while glutamine uses a Rag-independent route that needs Arf1 and the v-ATPase (Science 2015).
Own labJewell Lab, Department of Molecular Biology, UT Southwestern Medical Center (Dallas, Texas, USA). She studies how a cell 'tastes' particular nutrients and uses that to decide whether to grow.How cells sense specific nutrients to control mTORC1, growth and metabolism, and how this fails in disease including cancer.
Postdoc, about 2009-2015 (University of California San Diego)
In the labShowed that ULK1 starts autophagy by phosphorylating Beclin-1 and switching on the VPS34 lipid kinase (Nat Cell Biol 2013).
Own labRussell Lab, Department of Cellular and Molecular Medicine, University of Ottawa (Ottawa, Ontario, Canada). He studies how cells decide when to recycle their own parts, and how the growth switch mTOR controls that.Autophagy and its control by nutrient-sensing kinases (mTORC1, ULK1, AMPK), with links to Crohn's disease and cancer.
How links are chosen: a link appears only when two independent sources agree, a PubMed
paper the trainee wrote with the mentor at the mentor's institution and a separate page naming the mentor.
More on the method.
