What the field doesn't know
Two kinds of not-knowing, and they are not the same thing. The first is an experiment nobody has run. The second is a link this corpus does not hold, which may mean it does not exist, or may mean the Atlas is incomplete.
Where the timeline stops
4 nodes on the timeline have no children: the branch ends there because the experiment has not been done.
mTORC1-only, in humans?
Bi-steric inhibitors spare mTORC2 acutely. Whether that holds under chronic human dosing – and whether sparing mTORC2 removes the metabolic toxicity – is still open; the Phase 1 signal (SCH2025) is consistent with it but was uncontrolled.
Grows out of mTORC2 phosphorylates Akt, RapaLink-1
Frequency, not level?
Every mechanism on this branch was measured at steady state. If mTORC1 oscillates with feeding, growth-factor bursts and the cell cycle, then two cells with identical average activity could have opposite fates. Almost nothing in the literature is designed to detect that.
Grows out of 4E-BPs and TOP mRNAs, mTORC1 → ULK1: autophagy, mTORC1 → TFEB
Does timing matter?
Every human trial so far dosed on a fixed schedule chosen for convenience. If mTORC1 is phase-dependent, dose timing is an untested variable sitting inside every null result – including the one directly below this bud.
Grows out of Phase 3 misses endpoint, RapaLink-1
Human healthspan?
Untested – not disputed, not emerging. No completed trial has used a human ageing endpoint. This is the question the Atlas exists to keep visible.
Grows out of Mouse lifespan +14%, Phase 3 misses endpoint
Gaps computed from the corpus
Surfaced by joining the Atlas's entity graph to the kind of study behind each finding. Each one has its own page with the studies on both sides.
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