Lab lineage · Lab family
4 scientists over 3 generations of training, 1983–2006. The family starts with Raymond L. Erikson, whose lab trained John Blenis. The lab with the most trainees here is John Blenis's, with 2 people in this tree.
2 of the 4 have a full profile in the Atlas. Positions and dates come from the sources listed under each person and can lag behind job moves.
What the family's own labs work on
Read left to right: each line means "trained in this lab". Names with a profile are links. Dashed rings mark people without a profile yet. Open it in the interactive map →
Postdoc, about 1983-1989 (Harvard)
In the labWorked on Xenopus ribosomal S6 kinase II (later RSK), including its cloning and two-kinase-domain structure.
Own labBlenis Lab, Weill Cornell Medicine (New York, New York, USA). He studies the relay chains of enzymes that carry 'grow' signals from outside the cell to its protein factories.
mTORC2 & growth factors
Trained 2 people in this family ↓
Sources: PubMed 3368449 (1988) · ksmcb.or.kr · bmb.natsci.msu.edu
Blenis Lab, Weill Cornell Medicine · New York, New York, USA
Postdoc, 2001-2004 (Harvard Medical School, EMBO fellow)
In the labShowed that TSC1-TSC2 inhibits mTOR signalling and acts as a GAP for Rheb, placing Rheb between TSC and mTOR.
Own labFaculty profile, Cardiff University (Cardiff, Wales, United Kingdom). He uses rare genetic diseases where mTOR is stuck 'on' to learn how mTOR drives tumours and to find drugs for them.
Cancer & therapy
Also trained with Christopher G. Proud (PhD)
Sources: PubMed 12271141 (2002) · 2003 (in the Atlas) · PubMed 15094042 (2004) · profiles.cardiff.ac.uk
Postdoc, about 2001-2006 (Harvard Medical School)
In the labShowed that RSK1 phosphorylates TSC2 at Ser1798 downstream of Ras/MAPK, linking MAPK signalling to mTORC1 (PNAS 2004).
Own labRoux Lab, IRIC, Universite de Montreal (Montreal, Quebec, Canada). He studies how a second growth-signal pathway (Ras-MAPK) plugs into mTOR and the protein-making machinery.
Translation
Sources: PubMed 15342917 (2004) · PubMed 18955708 (2008) · mailman.bic.mni.mcgill.ca · doi.org
How links are chosen: a link appears only when two independent sources agree, a PubMed paper the trainee wrote with the mentor at the mentor's institution and a separate page naming the mentor. More on the method.
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