Jenna L. Jewell
Studies how cells sense nutrients such as amino acids to control growth and metabolism through mTORC1
Associate Professor of Molecular Biology · UT Southwestern Medical Center
Jewell Lab, Department of Molecular Biology, UT Southwestern Medical Center (Dallas, Texas, USA) ↗ Lab lineagetrained under Kun-Liang Guan →
Jenna Jewell is an Associate Professor in the Department of Molecular Biology at UT Southwestern Medical Center in Dallas. Her lab studies how cells sense nutrients to control cell growth and metabolism, and how this sensing goes wrong in human disease.
She earned her PhD at Indiana University with Debbie Thurmond and then trained as a postdoctoral fellow with Kun-Liang Guan at the University of California, San Diego. Her awards include an American Cancer Society Research Scholar Award and a FASEB Junior Investigator Award.
In the Atlas she is first author of JEW2015, a Science paper from the Guan lab. It showed that two amino acids reach mTORC1 by different routes: leucine works through the Rag GTPases, while glutamine can switch mTORC1 on even in cells that lack RagA and RagB, using the small GTPase Arf1 instead.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2015 | M | Metabolism. Differential regulation of mTORC1 by leucine and glutamine JEW2015 First author: leucine and glutamine activate mTORC1 by different routes, with glutamine using a Rag-independent, Arf1-dependent path (cells). |
Co-authors in the Atlas
People with a profile here who share at least one study with Jenna L. Jewell.
- Kun-Liang Guan Showed how growth-factor and energy signals reach mTORC1 through TSC2 and Rheb, and, in parallel with the Sabatini lab, that the Rag GTPases carry the amino-acid signal. His lab also found that AMPK and mTORC1 control autophagy by phosphorylating the kinase ULK1 at different sites
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