Edward Stuttfeld
Structural biologist who led the 2018 eLife study that gave the first detailed picture of the human mTORC2 core complex, working in Timm Maier's lab in Basel
Biozentrum, University of Basel, Timm Maier lab (2016–2021, most recent confirmed affiliation) · Biozentrum, University of Basel and Paul Scherrer Institut, Kurt Ballmer-Hofer group (VEGF receptors, 2009–2017)
Portrait: LinkedIn
mTORC2 is the second mTOR complex. It controls the kinase Akt, cell survival and the cell skeleton, and unlike mTORC1 it is not blocked by rapamycin. In 2018 Edward Stuttfeld was first author of an eLife paper, with senior authors Nenad Ban and Timm Maier, that used cryo-electron microscopy to show how the four core parts of human mTORC2 (mTOR, Rictor, SIN1 and mLST8) fit together. The structure helped explain why rapamycin does not act on mTORC2. A 2020 follow-up at 3.2 angstrom resolution, on which Stuttfeld is a co-author, pinned this to the tail end of Rictor. These are protein structure studies.
Stuttfeld began in vascular biology. With Kurt Ballmer-Hofer at the Paul Scherrer Institut in Villigen, Stuttfeld wrote a 2009 review on VEGF receptors, the receptors for a growth factor that drives blood-vessel growth, and later co-authored structural studies of VEGF receptors 1, 2 and 3.
In Timm Maier's group at the Biozentrum, Stuttfeld worked on large enzymes and signalling complexes. Besides the mTORC2 papers, Stuttfeld co-authored a 2018 Nature structure of human acetyl-CoA carboxylase, the first enzyme of fatty acid synthesis, and a 2021 eLife study of how DEPTOR binds and regulates both mTOR complexes. A current position could not be confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | M | Architecture of the human mTORC2 core complex STU2018 First author: solved the cryo-EM architecture of the human mTORC2 core complex. |
| 2020 | M | The 3.2-Å resolution structure of human mTORC2. SCA2020 Co-author of the 3.2 angstrom mTORC2 structure that traces rapamycin insensitivity to Rictor's C-terminus. |
Co-authors in the Atlas 9
People with a profile here who share at least one study with Edward Stuttfeld.
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- Alain Scaiola 2 shared studies Structural biologist in Nenad Ban's group at ETH Zurich who solved the 3.2-angstrom cryo-EM structure of human mTORC2 and works on how ribosomes are built and how new proteins are processed
- Daniel Boehringer 2 shared studies Electron microscopy specialist at ETH Zurich whose cryo-EM work underpins the Atlas structures of human mTORC1 and mTORC2
- Michael N. Hall 2 shared studies Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin
- Nenad Ban 2 shared studies Structural biologist known for atomic structures of the ribosome and for work on how cells make, fold and sort proteins.
- Stefan Imseng 2 shared studies Structural biologist from Timm Maier's group at the Biozentrum Basel who helped solve the first detailed structures of human mTORC1 and mTORC2 and then worked on a drug to block mTORC1 specifically
- Timm Maier 2 shared studies Solved some of the first cryo-EM structures of human mTORC1 (with Nenad Ban's group) and mTORC2, including a high-resolution map of mTORC2
- Evelyn Sauer Structural biologist at the Biozentrum Basel who worked on the structure of the mTOR kinase and contributed to the cryo-EM structures of human mTORC1 and mTORC2
- Christopher Aylett Structural biologist who solved the first cryo-EM architecture of human mTORC1 at ETH Zurich and now leads a cryo-EM group at Imperial College London
- Mitsugu Shimobayashi Metabolism researcher who trained with Michael Hall in Basel on mTOR in fat tissue and now leads a group at KU Leuven studying how fat and liver control sugar and lipid storage
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