Pathway link S6K1-NUCL
S6K1 Nucleotide synthesis
S6K1 activates Nucleotide synthesis.
S6K1 switches on an enzyme that starts building the raw materials for DNA – a direct line from growth signal to DNA parts.
The conditions it holds under
Mammalian cell studies including xenograft tumours (BEN2013, ROB2013, ALI2022). The evidence comes from cultured and tumour cells; whether non-dividing tissues use the same route is not shown.
- Time it takes
- minutes
- Step
- direct (one molecule acts on the other)
- Measured in
- mammalian cells
- Where in the cell
- cytosol
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2013 | M | Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1BEN2013 mTORC1-S6K1 stimulates de novo pyrimidine synthesis by phosphorylating CAD. |
| 2013 | M | Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesisROB2013 Quantitative phosphoproteomics show mTORC1 activates de novo pyrimidine synthesis. |
| 2022 | M | The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesisALI2022 Building a nucleotide needs a carbon donor, and cells get it from bicarbonate dissolved in their surroundings. This study shows mTORC1 does not just switch on the nucleotide enzymes - it also arranges the delivery of the raw material. Through S6K and the translation factor eIF4B, mTORC1 selectively increases translation of the mRNA for SLC4A7, a sodium-bicarbonate cotransporter, so more bicarbonate is pulled into the cell. Removing SLC4A7 from cells with hyperactive mTORC1 cut flux through both de novo purine and pyrimidine synthesis and slowed cell and tumor growth, without changing intracellular pH - so the transporter matters as a supply line, not as a pH regulator. A fourth distinct route by which mTORC1 feeds nucleotide synthesis, alongside CAD (BEN2013), the mitochondrial folate cycle (BEN2016) and demand coupling (VAL2017). |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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