Peng Gao
Directs the Northwestern metabolomics core that supplied mass-spectrometry metabolite measurements for three Ben-Sahra lab studies on how mTORC1 and ERK signalling drive nucleotide and SAM synthesis.
Research Associate Professor of Medicine and Director, Metabolomics Core Facility, Northwestern University Feinberg School of Medicine · postdoc, Proteomics and Mass Spectrometry Facility, Medical University of South Carolina · PhD in Drug Discovery and Biomedical Sciences, Medical University of South Carolina
Portrait: Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Peng Gao is listed with the Lurie Cancer Center Metabolomics Core Facility on three Ben-Sahra lab papers in the Atlas. Based on that affiliation, his contribution was metabolite measurement: SAM and methionine-cycle metabolites when mTORC1 drives MAT2A (VIL2021), purine synthesis flux after ERK2 phosphorylates PFAS (ALI2020), and purine and pyrimidine synthesis flux when SLC4A7 brings bicarbonate into mTORC1-driven cells (ALI2022).
Northwestern lists him as Research Associate Professor of Medicine and Director of the Metabolomics Core. His work there covers identifying and quantifying metabolites in cells, tissues and body fluids for preclinical and clinical cancer studies.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2020 | M | ERK2 phosphorylates PFAS to mediate posttranslational control of de novo purine synthesis ALI2020 Co-author from the Metabolomics Core: ERK2 phosphorylation of PFAS stimulates de novo purine synthesis. |
| 2021 | M | mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis VIL2021 Co-author from the Metabolomics Core: mTORC1 drives SAM synthesis through MAT2A and m6A-dependent protein synthesis. |
| 2022 | M | The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis ALI2022 Co-author from the Metabolomics Core: mTORC1 raises SLC4A7 translation to import bicarbonate for nucleotide synthesis. |
Co-authors in the Atlas
People with a profile here who share at least one study with Peng Gao.
- Brendan P. O'Hara 3 shared studies As lab manager of Issam Ben-Sahra's lab at Northwestern, contributed to its studies of how mTORC1 and ERK control nucleotide synthesis, SAM production and bicarbonate import
- Eunus S. Ali 3 shared studies Showed as a Ben-Sahra-lab postdoc that ERK2 directly activates the purine-synthesis enzyme PFAS, and that mTORC1 increases bicarbonate import through SLC4A7 to fuel nucleotide synthesis. His Kentucky lab studies how growth signals control nucleotide metabolism in cancer
- Issam Ben-Sahra 3 shared studies Showed as a postdoc in Brendan Manning's lab that mTORC1 drives both pyrimidine and purine synthesis, through two different mechanisms. His Northwestern lab has extended this to bicarbonate import, SAM synthesis and ERK control of purine production
- John M. Asara 3 shared studies Mass-spectrometry specialist whose core facility supplied metabolomics and proteomics for several mTOR studies, including measurements of purine, pyrimidine and SAM metabolism downstream of mTORC1.
- Elodie Villa 2 shared studies First author of the study showing that mTORC1 raises production of the methyl donor SAM through MAT2A and boosts m6A mRNA methylation to support protein synthesis and cell growth.
- Umakant Sahu 2 shared studies Showed that the building blocks of RNA also tell mitochondria how fast to burn fuel
Every researcher with a profile →
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