Pathway link FKBP12-MTORC1
FKBP12 mTORC1
FKBP12 binds mTORC1.
Only when it carries rapamycin does FKBP12 dock on mTORC1; the pair then blocks some, but not all, of what mTORC1 does. FKBP12 on its own does nothing to mTORC1.
The conditions it holds under
Biochemical and structural work on rat and bovine brain extracts, rodent and T cells, and a cryo-EM structure of human mTORC1. It defines how the drug-bound complex docks. FKBP12 alone does not inhibit mTORC1, and effects in whole animals are carried by the rapamycin edges, not this one.
- Time it takes
- minutes
- Step
- direct (one molecule acts on the other)
- Measured in
- rat and bovine brain (protein purification), rodent and T cells, cryo-EM of human mTORC1
- Where in the cell
- lysosome
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 1994 | M | RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORsSAB1994 Discovery of the protein RAFT1 (today's mTOR) as the direct target of the FKBP12-rapamycin complex; one of three 1994 reports (with Brown et al. and Chiu et al.) that identified mammalian TOR, three years after TOR was found in yeast. |
| 1995 | M | Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cellsSAB1995 Isolated mTOR as the FKBP12-rapamycin-associated protein controlling G1-S progression. |
| 1992 | M | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinasesCHU1992 Rapamycin-FKBP12 complex blocks growth-factor activation of p70 S6 kinase, linking the drug to a specific mitogenic pathway. |
| 1994 | M | A mammalian protein targeted by G1-arresting rapamycin-receptor complexBRO1994 Purified FRAP (mTOR) as the mammalian FKBP12-rapamycin target homologous to yeast TOR1/2. |
| 2015 | M | Architecture of human mTOR complex 1AYL2015 Cryo-EM architecture of human mTORC1 reveals its dimeric organization and active site access. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
Thank you. Your answer was counted anonymously.
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.