Maria M. Mihaylova
Studies how intestinal stem cells change with age and how diet shapes their metabolism
Assistant Professor of Biological Chemistry and Pharmacology · The Ohio State University · Pew Biomedical Scholar (2022)
Maria Mihaylova is an Assistant Professor in the Department of Biological Chemistry and Pharmacology at The Ohio State University. Her lab studies how intestinal stem and progenitor cells change with age, how those changes affect nutrient absorption and gut health, and what role diet plays.
She earned her PhD in biology from the University of California, San Diego and the Salk Institute in 2012, then did postdoctoral work at the Whitehead Institute until 2018. She was named a Pew Biomedical Scholar in 2022.
In the Atlas she is a co-author of GWI2008 from Reuben Shaw's lab at the Salk Institute, which showed that the energy sensor AMPK phosphorylates raptor to switch off mTORC1 when energy is low.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | M | AMPK phosphorylation of raptor mediates a metabolic checkpoint GWI2008 Co-author: AMPK phosphorylates raptor to enforce a metabolic checkpoint on mTORC1 (cells). |
Co-authors in the Atlas
People with a profile here who share at least one study with Maria M. Mihaylova.
- Benjamin E. Turk Kinase biochemist who studies how protein kinases choose their substrates; co-author on the discovery that AMPK phosphorylates raptor and on the study showing that mTORC1 sites differ in intrinsic substrate quality.
- Dana M. Gwinn First author of the 2008 study showing that the energy sensor AMPK switches off mTORC1 by phosphorylating raptor
- Daniel F. Egan Showed as first author that AMPK directly phosphorylates ULK1, linking low cellular energy to autophagy and mitophagy, and contributed to the finding that AMPK brakes mTORC1 by phosphorylating raptor
- Reuben J. Shaw Showed, in parallel with two other groups, that the tumour suppressor LKB1 directly activates AMPK, and that AMPK brakes mTORC1 by phosphorylating raptor. His Salk lab also linked AMPK to autophagy through ULK1 and helped explain how metformin acts in the liver
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