Dana M. Gwinn
First author of the 2008 study showing that the energy sensor AMPK switches off mTORC1 by phosphorylating raptor
Salk Institute for Biological Studies (2008)
Dana Gwinn did this work in Reuben Shaw's laboratory at the Salk Institute for Biological Studies in La Jolla, California, which is the affiliation PubMed gives for the study. The Atlas has no other sourced details of her career, so this profile covers only that paper.
In the Atlas she is first author of GWI2008. The paper found a second way that AMPK, the cell's low-energy alarm, shuts down mTORC1. Besides acting through TSC2, AMPK directly phosphorylates raptor, a core part of mTORC1, and this step is needed for cells to stop growing and pause their cell cycle when energy runs low.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2008 | M | AMPK phosphorylation of raptor mediates a metabolic checkpoint GWI2008 First author: AMPK phosphorylates raptor on two serines, a step required for mTORC1 shutdown and cell-cycle arrest under energy stress (cells). |
Co-authors in the Atlas
People with a profile here who share at least one study with Dana M. Gwinn.
- Benjamin E. Turk Kinase biochemist who studies how protein kinases choose their substrates; co-author on the discovery that AMPK phosphorylates raptor and on the study showing that mTORC1 sites differ in intrinsic substrate quality.
- Daniel F. Egan Showed as first author that AMPK directly phosphorylates ULK1, linking low cellular energy to autophagy and mitophagy, and contributed to the finding that AMPK brakes mTORC1 by phosphorylating raptor
- Maria M. Mihaylova Studies how intestinal stem cells change with age and how diet shapes their metabolism
- Reuben J. Shaw Showed, in parallel with two other groups, that the tumour suppressor LKB1 directly activates AMPK, and that AMPK brakes mTORC1 by phosphorylating raptor. His Salk lab also linked AMPK to autophagy through ULK1 and helped explain how metformin acts in the liver
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