Oliver's mTOR Atlas Evidence Platform
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Pathway link S6K1-LONGEVITY

S6K1 Longevity

S6K1 inhibits Longevity.

Removing S6K1 makes FEMALE mice live longer (about a fifth longer) and resist obesity. In male mice the same change did not significantly extend life – that difference is part of the result, not a footnote. Still strong evidence that one branch, not the whole pathway, drives much of the ageing effect.

Deleting S6K1 extends median lifespan in FEMALE mice (+19% in SEL2009); the effect was not significant in males. A separate study found that S6K1 loss protects against diet-induced obesity (UMX2004, which did not measure lifespan). Read the sex qualifier as part of the claim: this is the clearest evidence that one downstream branch, rather than mTORC1 as a whole, carries much of the ageing signal, and it is also the result whose qualifier is most often dropped in retelling.

The conditions it holds under

Female mice only in SEL2009 - the lifespan extension was not significant in males.

Time it takes
long exposure (days to weeks)
Step
indirect (through steps not drawn here)
Measured in
mouse
Reaches people?
not tested in people
How settled
emerging, few independent studies

Studies behind it

YearEvidenceStudy
2009 A Ribosomal protein S6 kinase 1 signaling regulates mammalian life spanSEL2009 Deleting S6K1 (a direct mTORC1 effector) extended lifespan in FEMALE mice (+19% median); the effect was not significant in males. It also protected against age-related bone, immune and motor decline. One of the clearest cases of the sex dimorphism catalogued in gap H6 - and a reminder that a single downstream branch, not mTORC1 as a whole, can carry much of the ageing signal.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
No researcher outside the project has checked this link yet.
Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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