{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1+unreleased",
  "live_matches_release": false,
  "archived_release": {
   "version": "2.0.1",
   "version_doi": "10.5281/zenodo.23090261",
   "date": "2026-10-01",
   "studies": 428
  },
  "data_fingerprint": "21bd609b55973b7b5b84e545fdde629d79115243854f1595680c534e6e1ef96f",
  "corpus_snapshot": "2026-11-02T19:05:06+0100",
  "source_commit": "1e9de0d56d4ea503818c4095460addc4a0c7f4a3",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas (live data, not an archived version; give corpus_snapshot and source_commit). doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "S6K1-LONGEVITY",
  "claim": "S6K1 inhibits Longevity",
  "source": {
   "name": "S6K1",
   "entity": "s6k1"
  },
  "target": {
   "name": "Longevity",
   "entity": "longevity"
  },
  "effect": "inhibits",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse"
  ],
  "mechanism": "Deleting S6K1 extends median lifespan in FEMALE mice (+19% in SEL2009); the effect was not significant in males. A separate study found that S6K1 loss protects against diet-induced obesity (UMX2004, which did not measure lifespan). Read the sex qualifier as part of the claim: this is the clearest evidence that one downstream branch, rather than mTORC1 as a whole, carries much of the ageing signal, and it is also the result whose qualifier is most often dropped in retelling.",
  "mechanism_beginner": "Removing S6K1 makes FEMALE mice live longer (about a fifth longer) and resist obesity. In male mice the same change did not significantly extend life – that difference is part of the result, not a footnote. Still strong evidence that one branch, not the whole pathway, drives much of the ageing effect.",
  "context": null,
  "boundary": "Female mice only in SEL2009 - the lifespan extension was not significant in males.",
  "boundary_tags": [
   "sex-specific",
   "single-species",
   "single-study"
  ],
  "conflict": null,
  "note": "Feeds the sex-dimorphism hypothesis H6 in Knowledge_Gaps. 2026-10-10: UMX2004 no longer cited as support for the lifespan arrow; it measured obesity and insulin sensitivity, not lifespan.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "untested",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "SEL2009"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/S6K1-LONGEVITY/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/S6K1-LONGEVITY.json"
 }
}