Pathway link MTORC2-MAM

mTORC2 → MAM (ER–mitochondria contacts)

mTORC2 activates MAM (ER–mitochondria contacts).

mTORC2 signalling also happens at a specific contact point between mitochondria and another cell structure - a sign that this pathway works at more than one location in the cell, not only on the lysosome.

mTORC2–Akt signalling localises to mitochondria-associated ER membranes and regulates mitochondrial physiology from there.

The conditions it holds under

Biochemical fractionation and imaging in cell lines; the functional contribution relative to plasma-membrane mTORC2 is not quantified.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

mitochondrion

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

← The whole pathway · This link as JSON