MAM (ER–mitochondria contacts)

Organelle · 1 studies in the Atlas

Mitochondria-associated ER membranes: a signalling platform distinct from the lysosome.

Where two organelles touch and talk. Where two organelles touch and talk.

mTORC2–Akt signalling localises here and regulates mitochondrial physiology (BET2013). Concrete evidence that mTOR signalling is not exclusively a lysosomal-surface phenomenon – the point that matters when the pathway is taught as though the lysosome were the only platform.

TL;DR. MAM (ER–mitochondria contacts) appears in 1 curated study in Oliver's mTOR Atlas: 1 at the molecular level (cells, biochemistry, structure). No study in people is recorded for it in the Atlas yet. It has 1 interaction in the curated pathway model.

In the pathway model

1 interaction in the curated mTOR pathway model. Each row is a claim with the evidence behind it; the evidence code is the kind of study, not its quality.

Interaction	Mechanism	Evidence	Studies
mTORC2 activates MAM (ER–mitochondria contacts) mechanism: localisation · this link in full · on the map table	mTORC2 signalling also happens at a specific contact point between mitochondria and another cell structure - a sign that this pathway works at more than one location in the cell, not only on the lysosome.mTORC2–Akt signalling localises to mitochondria-associated ER membranes and regulates mitochondrial physiology from there. Holds under: Biochemical fractionation and imaging in cell lines; the functional contribution relative to plasma-membrane mTORC2 is not quantified. plausible in people, not shown directly · emerging, few independent studies	M	BET2013

Evidence at a glance

Evidence	What it means	Studies
M	Molecular — cells, biochemistry, structure	1

No direct human evidence in the Atlas for this entity yet — everything below rests on animal or molecular work.

Studies

Year	Evidence	Study
2013	M	mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology BET2013 mTORC2-Akt signalling localizes to mitochondria-associated ER membranes to regulate mitochondrial function.

Cite this page

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Barton, O. (2026). MAM (ER–mitochondria contacts) [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/organelle/mam-ermitochondria-contacts/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_organelle_mam_ermitochondria_contacts,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: MAM (ER–mitochondria contacts)},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/organelle/mam-ermitochondria-contacts/},
  doi          = {10.5281/zenodo.22059963}
}

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