Zhao Lai
Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.
University of Texas at San Antonio
Portrait: UT San Antonio
Zhao Lai is a co-author of MARCHANT2026 and MAR2026B. Both studies activated mTORC1 permanently in mouse skeletal muscle by deleting a negative regulator of the pathway (the GATOR1 complex, or Depdc5 in the aged-mice study). The muscle showed more inflammatory gene expression, and dietary rapamycin only partly reversed it.
In PubMed Zhao Lai is listed in the Department of Molecular Medicine and the Greehey Children's Cancer Research Institute at the University of Texas at San Antonio.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance. MARCHANT2026 Co-author. Constitutive muscle mTORC1 activation raises inflammation but does not by itself impair glucose tolerance. |
| 2026 | A | Constitutive Activation of Skeletal Muscle mTORC1 Drives Pro-Inflammatory Gene Expression in Skeletal Muscle of Aged Mice. MAR2026B Co-author. In 27-month-old mice, constitutive muscle mTORC1 activation drives pro-inflammatory gene expression. |
Co-authors in the Atlas 5
People with a profile here who share at least one study with Zhao Lai.
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- Blake B. Rasmussen 2 shared studies Muscle physiologist who studies how mTORC1 and nutrient signaling control muscle growth and loss in people, including during exercise and aging.
- Erik D. Marchant 2 shared studies Graduate student in Blake Rasmussen's lab in San Antonio who studies what overactive mTORC1 in skeletal muscle does to metabolism, inflammation and exercise adaptation in aging and overnutrition
- Hanna Kalenta 2 shared studies Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.
- Jacquelyn May 2 shared studies Co-author of two 2026 studies on constitutive mTORC1 activation in skeletal muscle from the Rasmussen laboratory.
- Adam B. Salmon Biologist of aging at UT Health San Antonio whose work in this Atlas spans rapamycin in mice and in common marmosets. He is a co-author on the Interventions Testing Program reports from the San Antonio site and on the marmoset rapamycin studies on blood markers, epigenetic age and the salivary gland
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