Hongxuan Feng
Neurologist at Suzhou Municipal Hospital and senior author of a 2026 stroke study proposing PIP4K2A as a protector of brain tissue through AKT/mTOR signalling and autophagy
Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Gusu School, Nanjing Medical University (at the time of the study, 2026)
When a stroke blocks a brain artery, doctors try to restore blood flow as quickly as possible. The returning blood, however, causes a second wave of damage called ischemia/reperfusion injury. The 2026 study led by Bodun Ma, with Hongxuan Feng as senior author, looked at PIP4K2A, a lipid kinase, in laboratory models of this injury.
Raising PIP4K2A levels reduced the injury. The team linked the effect to two things: less of a TRIB3-p62 protein complex, which can clog autophagy, the cell's recycling system, and changed AKT/mTOR signalling, so that autophagy could run properly again. The study proposes PIP4K2A-AKT/mTOR as a protective axis, a result from experimental models that has not been tested in patients.
PubMed lists Hongxuan Feng at the Department of Neurology of the Affiliated Suzhou Hospital of Nanjing Medical University. No official profile could be checked, so the position is given as at the time of the study.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling. MA2026 Senior author: led the study showing that PIP4K2A lessens ischemia/reperfusion brain injury by reducing the TRIB3-p62 complex and adjusting AKT/mTOR signalling to restore autophagy. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Hongxuan Feng.
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- Bodun Ma Neurology researcher in Suzhou and first author of a 2026 study on how the enzyme PIP4K2A protects the brain after stroke by restoring autophagy through AKT/mTOR
- Mei Li Scientist at the Pediatrics Research Institute of Children's Hospital of Soochow University studying brain injury, who contributed to a study of how PIP4K2A protects the brain after stroke
- Shuai Yu Neurology researcher who contributed to a study showing that the lipid kinase PIP4K2A protects the brain after ischaemic stroke by relieving a block on autophagy and boosting AKT/mTOR signalling
- Xiaotian Yu Stroke neurology researcher who contributed to a study of how PIP4K2A limits brain injury after ischaemia and reperfusion through the TRIB3–p62 and AKT–mTOR pathways
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