George D. Yancopoulos
Industry scientist who co-founded Regeneron and led drug discovery there; in this Atlas he is senior author of an early paper showing that Akt/mTOR signalling controls muscle size.
Founding Scientist, President & Chief Scientific Officer, Regeneron Pharmaceuticals (joined 1989) · Member, US National Academy of Sciences (2004) · industry scientist
Regeneron Pharmaceuticals (Tarrytown, New York, USA) ↗
Portrait: Regeneron Pharmaceuticals
George Yancopoulos is a physician-scientist who joined Regeneron in 1989 as its founding scientist, working with co-founder Leonard Schleifer. He is now the company's president and chief scientific officer. He is listed as a principal inventor or developer on several approved drugs from Regeneron and was elected to the US National Academy of Sciences in 2004.
The study in the Atlas, published in Nature Cell Biology in 2001, came from Regeneron's muscle biology group led by Sue Bodine. It asked what makes skeletal muscle grow or shrink in living animals.
The team found that the Akt/mTOR pathway turns up during muscle growth and down during wasting. Rapamycin blocked growth, and switching on the pathway genetically was enough to cause growth and to oppose muscle loss from disuse.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2001 | A | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo BOD2001 Showed in rats that Akt/mTOR signalling is needed and sufficient for skeletal muscle hypertrophy and can oppose atrophy; Yancopoulos was last author, with Bodine as first author. |
| 2001 | M | Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways ROM2001 Shows IGF-1 drives muscle fiber hypertrophy through Akt, via both the mTOR and GSK3 branches, in cultured myotubes, establishing mTOR as a central node for muscle growth signaling. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with George D. Yancopoulos.
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- Sue C. Bodine 2 shared studies Showed that turning on the Akt-mTOR pathway is enough, by itself, to make skeletal muscle grow and to stop it from wasting away
- Trevor N Stitt 2 shared studies Regeneron scientist who worked in David Glass and George Yancopoulos's muscle program on the 2001 papers showing that the Akt/mTOR pathway drives muscle growth and protects against muscle wasting
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