Pathway link SESN2-GATOR2

Sestrin2 ⊣ GATOR2

Sestrin2 inhibits GATOR2.

When there's no leucine, Sestrin2 grabs onto GATOR2 and holds the whole growth pathway shut.

When leucine is scarce, free Sestrin2 clamps onto GATOR2 and blocks it, keeping the whole pathway switched off.

The conditions it holds under

Mammalian cell studies (CHA2014, PAR2014, WOL2015). Shows leucine sensing in cultured cells; the importance of this sensor in whole animals and people is not tested by these studies.

Time it takes

seconds

Step

direct (one molecule acts on the other)

Measured in

human cells

Where in the cell

cytosol

Reaches people?

plausible in people, not shown directly

How settled

settled in the literature

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“Inhibits” describes the effect on the target's activity, not on how much of it there is.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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