Pathway link PI3K-AKT
PI3K Akt/PKB
PI3K activates Akt/PKB.
That lipid pulls Akt to the cell membrane, where it gets switched on.
The conditions it holds under
Mammalian cell study (LIU2015) plus a review (CAN2002). Cell biochemistry; not tested in whole animals or in people by the cited sources.
PIP3 recruits Akt; recruitment alone does not activate it. Full activation additionally needs PDK1 (T308) and mTORC2 (S473), so the strength of this link depends on the activity of both of those.
- Time it takes
- seconds
- Step
- indirect (through steps not drawn here)
- Measured in
- mammalian cells
- Where in the cell
- plasma membrane
- Reaches people?
- plausible in people, not shown directly
- How settled
- settled in the literature
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2002 | R | The phosphoinositide 3-kinase pathwayCAN2002 Review establishing PI3K as a central signaling hub controlling cell survival, metabolism, and growth downstream of growth-factor receptors and upstream of Akt and mTOR. |
| 2015 | M | PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase ComplexLIU2015 PIP3 relieves SIN1 PH-domain autoinhibition to activate the mTORC2 kinase complex. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.
Thank you. Your answer was counted anonymously.