Pathway link MTORC2-PROSTATE

mTORC2 – Prostate cancer

mTORC2 required-for Prostate cancer.

Prostate tumours caused by losing a specific tumour-suppressor gene (Pten) need mTORC2 to develop – normal prostate tissue doesn't, at least in mice.

Prostate cancer driven by Pten loss needs mTORC2 to develop; normal prostate does not. A real therapeutic window, at least in mice.

The conditions it holds under

Single-study edge in this corpus (GUE2009). Shown in Pten-null mouse prostate only: mTORC2 (Rictor) is required for tumours to develop in that genetic background, while normal prostate epithelium is not dependent on it. Mouse only - not tested in another species in this corpus, and not shown in human prostate cancer.

Time it takes

long exposure (days to weeks)

Step

indirect (through steps not drawn here)

Measured in

mouse

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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