{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC2-PROSTATE",
  "claim": "mTORC2 required-for Prostate cancer",
  "source": {
   "name": "mTORC2",
   "entity": "mtorc2"
  },
  "target": {
   "name": "Prostate cancer",
   "entity": "prostate-cancer"
  },
  "effect": "required-for",
  "type": "functional-consequence",
  "directness": "indirect",
  "timescale": "chronic",
  "compartment": null,
  "map_band": "outcome",
  "species": [
   "mouse"
  ],
  "mechanism": "Prostate cancer driven by Pten loss needs mTORC2 to develop; normal prostate does not. A real therapeutic window, at least in mice.",
  "mechanism_beginner": "Prostate tumours caused by losing a specific tumour-suppressor gene (Pten) need mTORC2 to develop – normal prostate tissue doesn't, at least in mice.",
  "context": null,
  "boundary": "Single-study edge in this corpus (GUE2009). Shown in Pten-null mouse prostate only: mTORC2 (Rictor) is required for tumours to develop in that genetic background, while normal prostate epithelium is not dependent on it. Mouse only - not tested in another species in this corpus, and not shown in human prostate cancer.",
  "note": "The arrow means mTORC2 is required for Pten-loss-driven prostate cancer to develop in mice. It does not claim that mTORC2 causes prostate cancer, and it says nothing about human disease.",
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "GUE2009"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC2-PROSTATE/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC2-PROSTATE.json"
 }
}