Oliver's mTOR Atlas Evidence Platform
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Pathway link MTORC1-MITO

mTORC1 Mitochondrial biogenesis

mTORC1 activates Mitochondrial biogenesis.

mTORC1 boosts the cell's mitochondria – its power plants – two ways at once: through a gene-activating complex, and by freeing up 4E-BP.

mTORC1 raises mitochondrial output two ways: through a YY1-PGC-1alpha transcription complex, and by relieving 4E-BP so mitochondrial proteins get translated.

The conditions it holds under

Shown in cultured cells and skeletal muscle (CUN2007) and mammalian cell lines (MOR2013). One organismal result points the other way: adipose-specific Raptor deletion raised mitochondrial respiration (POL2008), see MTORC1-OXPHOS.

Time it takes
hours
Step
indirect (through steps not drawn here)
Measured in
mammalian cells
Where in the cell
mitochondrion
Reaches people?
plausible in people, not shown directly
How settled
emerging, few independent studies

Studies behind it

YearEvidenceStudy
2007 M mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexCUN2007 Showed mTOR isn't just about building proteins - it also runs the cell's POWER plants. mTORC1 drives mitochondrial gene expression and oxygen consumption through a YY1-PGC-1alpha transcriptional program; block mTOR with rapamycin and mitochondrial output falls. Explains part of why mTOR inhibition reshapes metabolism.
2013 M mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulationMOR2013 mTORC1 controls mitochondrial biogenesis and activity through 4E-BP-dependent translation.
2008 A Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophyBEN2008 In mice, muscle-specific raptor loss (not rictor) causes dystrophy, showing mTORC1 is essential for muscle homeostasis.

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by
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Curator sign-off
Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
Curated by
Oliver Barton, with AI help for drafting; see how links are checked.

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