{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "MTORC1-MITO",
  "claim": "mTORC1 activates Mitochondrial biogenesis",
  "source": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "target": {
   "name": "Mitochondrial biogenesis",
   "entity": "mitochondrial-biogenesis"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "mito",
  "map_band": "mito",
  "species": [
   "mammalian cells"
  ],
  "mechanism": "mTORC1 raises mitochondrial output two ways: through a YY1-PGC-1alpha transcription complex, and by relieving 4E-BP so mitochondrial proteins get translated.",
  "mechanism_beginner": "mTORC1 boosts the cell's mitochondria – its power plants – two ways at once: through a gene-activating complex, and by freeing up 4E-BP.",
  "context": null,
  "boundary": "Shown in cultured cells and skeletal muscle (CUN2007) and mammalian cell lines (MOR2013). One organismal result points the other way: adipose-specific Raptor deletion raised mitochondrial respiration (POL2008), see MTORC1-OXPHOS.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "medium",
   "human_relevance": "plausible",
   "consensus": "emerging"
  },
  "evidence": {
   "kind": "Genetic epistasis",
   "strongest": {
    "code": "A",
    "label": "Animal model"
   },
   "supporting": [
    "CUN2007",
    "MOR2013",
    "BEN2008"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/MTORC1-MITO/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/MTORC1-MITO.json"
 }
}