Pathway link LYSOBIO-LYSOSOME
Lysosomal biogenesis Lysosome
Lysosomal biogenesis activates Lysosome.
More, fresher lysosomes change the very platform that controls mTORC1 – closing a loop back to where the signal started.
The conditions it holds under
SET2012 establishes lysosome-to-nucleus signalling via mTOR and TFEB; the quantitative effect of compartment size on mTORC1 output is not resolved.
- Time it takes
- hours
- Step
- direct (one molecule acts on the other)
- Measured in
- mammalian cells
- Where in the cell
- lysosome
- Reaches people?
- plausible in people, not shown directly
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEBSET2012 A lysosome-to-nucleus mechanism uses mTOR-dependent TFEB phosphorylation to sense lysosomal state. |
| 2011 | M | TFEB links autophagy to lysosomal biogenesisSET2011 Showed that TFEB drives a coordinated autophagy and lysosomal gene programme during starvation. In this paper TFEB was regulated by ERK2 phosphorylation; its control by mTORC1 at the lysosome was established in later work (SET2012). |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
← The whole pathway · This link as JSON
Was this page useful?
Thank you. Your answer was counted anonymously.
Spotted something wrong or out of date about this link?
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.