Pathway link LOAD-MTORC1

Resistance exercise / mechanical load → mTORC1

Resistance exercise / mechanical load activates mTORC1.

Working a muscle raises mTORC1 activity in it. When volunteers took rapamycin, the rise in muscle protein building after exercise was blocked, so in people, and not only in cell dishes, mTORC1 sits between the effort and the response. The map draws one arrow, but load reaches mTORC1 by several routes, and this result does not show which one carries the signal.

Mechanical loading raises mTORC1 signalling in skeletal muscle. Rapamycin given to human volunteers blocks the contraction-induced increase in muscle protein synthesis, placing mTORC1 causally between the load and the response.

The conditions it holds under

Compressed: load reaches mTORC1 through several routes, only some of which need IGF-1, and the map draws one arrow. The human evidence establishes that mTORC1 is required, not which upstream route carries the signal.

Time it takes

hours

Step

indirect (through steps not drawn here)

Measured in

human, mouse

Where in the cell

lysosome

Reaches people?

shown in people

How settled

settled in the literature

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

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