{
 "meta": {
  "api_version": "1.0.0",
  "dataset_version": "2.0.1",
  "corpus_snapshot": "2026-10-12T22:59:14+0200",
  "source_commit": "93739c9d195dc39e47eecfabc3cab2565a2f256f",
  "license": "CC-BY-4.0",
  "cite": "Barton O. Oliver's mTOR Atlas. doi:10.5281/zenodo.22059963",
  "docs": "https://mtor-atlas.org/api/"
 },
 "data": {
  "id": "LOAD-MTORC1",
  "claim": "Resistance exercise / mechanical load activates mTORC1",
  "source": {
   "name": "Resistance exercise / mechanical load",
   "entity": "resistance-exercise-mechanical-load"
  },
  "target": {
   "name": "mTORC1",
   "entity": "mtorc1"
  },
  "effect": "activates",
  "type": "signal-relay",
  "directness": "indirect",
  "timescale": "hours",
  "compartment": "lyso",
  "map_band": "lyso",
  "species": [
   "human",
   "mouse"
  ],
  "mechanism": "Mechanical loading raises mTORC1 signalling in skeletal muscle. Rapamycin given to human volunteers blocks the contraction-induced increase in muscle protein synthesis, placing mTORC1 causally between the load and the response.",
  "mechanism_beginner": "Working a muscle raises mTORC1 activity in it. When volunteers took rapamycin, the rise in muscle protein building after exercise was blocked, so in people, and not only in cell dishes, mTORC1 sits between the effort and the response. The map draws one arrow, but load reaches mTORC1 by several routes, and this result does not show which one carries the signal.",
  "context": null,
  "boundary": "Compressed: load reaches mTORC1 through several routes, only some of which need IGF-1, and the map draws one arrow. The human evidence establishes that mTORC1 is required, not which upstream route carries the signal.",
  "note": null,
  "consensus_contested": false,
  "curation_contested": false,
  "contested": false,
  "confidence": {
   "mechanistic": "high",
   "human_relevance": "established",
   "consensus": "established"
  },
  "evidence": {
   "kind": "Pharmacological",
   "strongest": {
    "code": "H",
    "label": "Human study"
   },
   "supporting": [
    "DRU2009",
    "BOD2001"
   ],
   "conflicting": []
  },
  "external_refs": [],
  "reviewed": null,
  "updated": null,
  "checked": null,
  "review_status": "unreviewed",
  "reviewer": null,
  "curation_status": "Proposed",
  "url": "https://mtor-atlas.org/relation/LOAD-MTORC1/",
  "api_url": "https://mtor-atlas.org/api/v1/relations/LOAD-MTORC1.json"
 }
}