Corrections log
Every recorded correction to a study record's finding or supporting fields, with the curator's own reason for the change, plus any change to the method itself. This is the log referenced from About & Methodology's correction policy.
Changes to the method
Changes affecting how every record is read, rather than a fix to one study.
| Date | Change | Why |
|---|---|---|
| 2026-09-07 | Evidence codes renamed from A–D to S / H / A / M / R, and reviews split out | The old codes ran A, B, C, D. However carefully the caption said “a tier is not a grade”, a lettered ladder is read as a school report — and 61% of the corpus sat at the bottom letter, including the experiments that established the pathway. The codes now name the system a finding was established in and carry no order: S = synthesis of human data, H = human study, A = animal model, M = molecular. Narrative reviews, previously grouped with primary molecular work under the same letter, now carry their own R and are drawn outlined, like preprints and registered trials, because a review is a different form of document rather than a weaker one. Nothing in the underlying data changed and no study was re-graded: the stored values are untouched, only what a reader sees. The change was prompted by a public comment from Prof. Brendan Manning (Harvard T.H. Chan School of Public Health), who pointed out that rigorous mechanistic work should not be weighted down merely for not yet having been shown in humans. |
| 2026-09-07 | Static pages were painting a retired palette | The evidence-marker colours were flattened to equal brightness in August 2026, precisely so no marker could look duller than another. That fix reached the interactive Atlas but not the 471 static pages, which kept the old green-to-grey ramp, and their badges carried no explanatory tooltip at all. Both are fixed, and the automated palette check now covers the static generators as well. |
Corrections to individual records
46 corrections on record, from 35 distinct study records.
Dates below mark the audit round in which each correction was made, not the individual edit's own timestamp -- neither source file this page reads carries a true per-entry date. See About & Methodology for how the review process itself works.
| Date | Study | Field | What changed and why |
|---|---|---|---|
| 2026-07-29 | ZHU2026 | finding | A mouse toxicology model cannot establish a therapeutic target. |
| 2026-07-29 | WAG2014 | finding | n-of-1 exceptional-responder case stated as an established explanation. |
| 2026-07-29 | VAL2022 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | VAL2017 | finding | Cell-line finding stated as an unscoped causal law. |
| 2026-07-29 | THO2012 | finding | 'settle ... almost entirely' overstates one cell-line ribosome-profiling study. |
| 2026-07-29 | SHW2004 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | SHA2004 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | SEL2009 | finding | F5: sex-specificity omitted |
| 2026-07-29 | SEL2009 | ai_effect | F5 |
| 2026-07-29 | SCH2025 | finding | Phase I, open-label, single-arm, n=57, no comparator: cannot support 'direct clinical confirmation' or a causal attribution to mTORC2 sparing. |
| 2026-07-29 | SCH2025 | ai_effect | 'confirming' asserts causality from an uncontrolled trial. |
| 2026-07-29 | ROD2011 | ai_effect | Species/system scope added to a causal claim from cell culture. |
| 2026-07-29 | MCC2011 | finding | 'prove' overstates a single n=89 RCT; 'show' is proportional to a randomised design. |
| 2026-07-29 | MCC2011 | finding | 'proof' overstates; added the withdrawal caveat the study itself reports. |
| 2026-07-29 | MAT2017 | finding | 'confirms' overstates a post-hoc comparison of two non-harmonised cohorts. |
| 2026-07-29 | MAR2026 | finding | Observational cohort reported without a confounding caveat. |
| 2026-07-29 | MA2005 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | LV2026 | finding | Species scope added; 'systemic aging' narrowed to the measured phenotypes. |
| 2026-07-29 | LEE2010 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | LAM2012 | finding | Species scope added: the mTORC2/insulin-resistance link is mouse data. |
| 2026-07-29 | LAM2012 | ai_effect | Species scope added. |
| 2026-07-29 | LAM2012 | tier | F4: whole-animal mouse metabolic phenotyping graded D/in-vitro |
| 2026-07-29 | LAM2012 | pyramid | F4 |
| 2026-07-29 | LAM2012 | model | F4 |
| 2026-07-29 | KRU2010 | finding | Uncontrolled Phase II result presented without design caveat. |
| 2026-07-29 | KIM2003 | finding | 'proved' is absolute language for a biochemistry paper. |
| 2026-07-29 | KAL2010 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | JOH2013 | finding | A narrative review (outside the evidence hierarchy) cannot be 'definitive'. |
| 2026-07-29 | IYE2012 | finding | n-of-1 case described with 'pinpoints', which implies established causality. |
| 2026-07-29 | HSI2012 | finding | 'therapeutic proof-of-concept' read as clinical; scoped to preclinical. |
| 2026-07-29 | HSI2012 | finding | Removed 'proof' entirely rather than relying on a linter exemption. |
| 2026-07-29 | HAR2014 | finding | 'proof' is absolute language. |
| 2026-07-29 | HAR2004 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | GUE2006 | finding | 'definitive' is an absolute claim; the substance (mouse genetics) is unchanged. |
| 2026-07-29 | GUE2006 | finding | 'proved' -> 'showed'; species scope added. |
| 2026-07-29 | GAO2026 | finding | Mechanistic/in vitro work described as identifying a clinical therapeutic target. |
| 2026-07-29 | FRA2013 | finding | 'proof that blocking mTOR works' generalised beyond the trial population; scoped to the disease and design. |
| 2026-07-29 | FOR2010 | (new record) | F6/F7/F8/F9/F14: landmark paper added |
| 2026-07-29 | FLY2013 | finding | 'proof' plus an unscoped generalisation from one mouse cardiac study. |
| 2026-07-29 | DEN2026 | pyramid | F4: tier C with pyramid 5 in the same record |
| 2026-07-29 | BO2026 | finding | In-silico + single cell-line work described as a demonstration. |
| 2026-07-29 | BEN2008 | finding | Species scope added. |
| 2026-07-29 | BEN2008 | ai_effect | Species scope added. |
| 2026-07-29 | BAN2014 | finding | Large observational cohort framed in a way that invites a causal reading. |
| 2026-07-29 | ARR2015 | finding | F1: cited for a lifespan claim it never measured |
| 2026-07-29 | ARR2015 | ai_effect | F1 |