Screening log

A curated database is only as trustworthy as its selection. This page records where the Atlas looked, when, and why a candidate was taken in or turned down, so the choices can be checked and challenged. How a study gets into the main corpus is described on the methodology page.

Last edited 31 Oct 2026 · 20 search runs · 2 added · 18 rejected

What is logged so far

On the horizon: trials and preprints

The bar. A trial or preprint is listed only if it asks about the temporal dynamics of mTOR: oscillation, pulses, time courses, circadian regulation, or dosing schedule as the question. Studies of mTOR with standard continuous dosing, and studies of other pathways, do not qualify.

Where it looks. ClinicalTrials.gov: rapamycin, sirolimus, everolimus or mTOR combined with autophagy, ageing or longevity, active recruiting statuses. bioRxiv and medRxiv: cell biology and molecular biology preprints in a rolling window of 3 to 30 days.

In use since 30 Sep 2026.

Not logged yet

These parts of the screening happen, but their individual decisions were not recorded, so an empty space here does not mean nothing was turned down.

Weekly screening of the bims-auttor digest (biomed.news) for the main corpus: only issue dates are kept, not per-paper decisions.
Daily PubMed check for the main corpus: new studies are added to the Atlas, but rejected candidates and reasons have not been recorded.

Decisions

Date	Candidate	Decision	Reason
30 Oct 2026	10.64898/2026.10.27.762351Tryptophan and hlh-30 in C. elegans	Rejected	Not about the dynamics of mTOR.
23 Oct 2026	10.64898/2026.10.16.759620PPTC7, NIX and BNIP3 in mitophagy	Rejected	Not about mTOR.
18 Oct 2026	10.64898/2026.10.09.757844Plakoglobin and insulin/PI3K/AKT/FoxO signalling	Rejected	Not about the time course of mTOR.
17 Oct 2026	10.64898/2026.10.09.757842ERK FLIM biosensor	Rejected	Measures ERK, not mTOR.
13 Oct 2026	10.64898/2026.06.16.732532TRPML1 and AMPK in diabetes	Rejected	Not about the time course of mTOR.
2 Oct 2026	NCT07774676Understanding the Effects of Obesity on Autophagic and mTORC1 Signalling Following Resistance Exercise and Protein Ingestion in Skeletal Muscle	Added	Tracks mTORC1 movement to the lysosome and autophagic flux at several time points after a stimulus, in lean and obese people.
1 Oct 2026	NCT04742777	Rejected	Did not clear the temporal-dynamics bar. mTOR inhibition in older adults with standard dosing and no timing or schedule question.
1 Oct 2026	NCT05036226	Rejected	Did not clear the temporal-dynamics bar. An autophagy-combination oncology trial (COAST) with standard continuous dosing.
1 Oct 2026	NCT05237687	Rejected	Did not clear the temporal-dynamics bar. Sirolimus in older adults, a biomarker trial with standard dosing.
1 Oct 2026	NCT06133634	Rejected	Did not clear the temporal-dynamics bar. A fisetin senolytic trial, not an mTOR trial.
1 Oct 2026	NCT06789900	Rejected	Did not clear the temporal-dynamics bar. Everolimus with exercise for bone (RapaLoad), standard continuous dosing.
30 Sep 2026	10.64898/2026.08.28.747564The mTOR pathway drives daily physiology	Added	Strong match to the bar: mTOR and daily physiology. Added under the standing instruction to add strong matches automatically.
30 Sep 2026	NCT05949658	Already listed	Already on the list with its own entry; not evaluated again.
30 Sep 2026	NCT06658093	Already listed	Already on the list with its own entry; not evaluated again.
30 Sep 2026	NCT06727305	Already listed	Already on the list with its own entry; not evaluated again.
30 Sep 2026	NCT05836025	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT06682767	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT07058974	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT07092618	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT07191353	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT07354620	Rejected	Did not clear the temporal-dynamics bar.
30 Sep 2026	NCT07443826	Rejected	Did not clear the temporal-dynamics bar. Assessed again on 2026-10-23: a gene-therapy trial (AAV-follistatin with a VEGF plasmid, Unlimited Biotechnology), not an mTOR trial.
30 Sep 2026	NCT07475546	Rejected	Did not clear the temporal-dynamics bar.

Search runs

Each run is one pass of the daily check. A dash means the number was not recorded.

Date	Source	What was searched	Trials returned / new	Preprints scanned	Result
30 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints (run twice that day with the same result) (window: 3 days)	15 / 0	30	No new trial. Nothing cleared the bar.
29 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints (window: 7 days)	15 / 0	30	No new trial. Nothing cleared the bar.
28 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints (window: 7 days)	15 / 0	30	No new trial. Nothing cleared the bar.
25 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints (window: 7 days)	15 / 0	—	No new trial. Nothing cleared the bar.
23 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints, 16 to 19 October (window: 4 days)	15 / 0	30	No new trial; NCT07443826 was assessed again and rejected. Nothing cleared the bar.
21 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints, 14 to 16 October (window: 3 days)	15 / 0	30	No new trial. Nothing cleared the bar.
19 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; bioRxiv search without a keyword	15 / 0	—	No new trial. The preprint search returned only older cell-biology papers, none on the topic.
18 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints, 12 to 14 October (window: 3 days)	15 / 0	30	No new trial. Nothing cleared the bar.
17 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell and molecular biology preprints (window: 7 days)	15 / 0	60	No new trial. Nothing cleared the bar.
13 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints, 10 to 12 October (window: 3 days)	15 / 0	—	No new trial. Nothing cleared the bar.
12 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; bioRxiv API, 5 to 11 October (window: 7 days)	16 / 0	—	No new trial. Nothing cleared the bar.
10 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell and molecular biology preprints (window: 7 days)	16 / 0	60	No new trial. Nothing cleared the bar.
9 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell and molecular biology preprints (window: 7 days)	14 / 0	60	No new trial. Nothing cleared the bar.
8 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell biology preprints directly, molecular biology through the bioRxiv API after the first route failed (window: 7 days)	16 / 0	60	No new trial. Nothing cleared the bar.
7 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell and molecular biology preprints (window: 7 days)	15 / 0	60	No new trial. Nothing cleared the bar; the nearest preprint concerned circadian timing of AMPK, not mTOR.
5 Oct 2026	ClinicalTrials.gov; bioRxiv	Same trial query; cell and molecular biology preprints (window: 7 days)	16 / 0	60	No new trial. Nothing cleared the bar.
3 Oct 2026	ClinicalTrials.gov; bioRxiv	Rapamycin, sirolimus, everolimus or mTOR with autophagy, ageing or longevity, active statuses; plus a circadian and chronotherapy search; preprints in cell and molecular biology (window: 10 days)	16 / 0	60	No new trial. The circadian search returned no results. Nothing cleared the bar.
2 Oct 2026	ClinicalTrials.gov; bioRxiv	Trials plus cell-biology and molecular-biology preprints, last 30 days (window: 30 days)	— / 1	—	1 trial added; no preprint cleared the bar.
1 Oct 2026	ClinicalTrials.gov; bioRxiv; medRxiv	Trials plus cell-biology and molecular-biology preprints, last 14 days (window: 14 days)	— / 5	—	5 new trials rejected; no new preprint cleared the bar.
30 Sep 2026	ClinicalTrials.gov; bioRxiv	First run of the watch: candidate trials and preprints on the temporal dynamics of mTOR	— / —	—	1 preprint added, 8 trials rejected, 3 trials already on the list.

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