Xingrong Du
Studies how cellular metabolism and signaling shape the function of T cells, regulatory T cells and dendritic cells in tumor immunity, autoimmunity and immunodeficiency.
Principal investigator, Institute of Metabolism and Integrative Biology (IMIB), Fudan University
Du Group, Institute of Metabolism and Integrative Biology, Fudan University (Shanghai, China) ↗
Portrait: Institute of Metabolism and Integrative Biology, Fudan University
Xingrong Du is a principal investigator at the Institute of Metabolism and Integrative Biology at Fudan University in Shanghai. According to the institute's page, her group studies how metabolism and the signals that control it shape immune cells, including T cells, regulatory T cells and dendritic cells, in tumor immunity, autoimmunity and immunodeficiency.
The study in the Atlas asks how activated T cells keep their supply of amino acids high enough to grow and divide. The team found that two protein complexes, CORVET and HOPS, help the cell take in nutrients from outside by macropinocytosis, a kind of cell drinking. Without them the T cells run short of amino acids, a stress program called the integrated stress response switches on, and mTORC1 shuts down.
Restoring mTORC1 activity rescued the failure to multiply, while deleting the cell-death gene BIM rescued survival. This separated two ways the cells fail and placed nutrient uptake upstream of the lysosomal amino-acid sensors that control mTORC1.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells WANG2026 Showed that CORVET/HOPS complexes supply amino acids to activated T cells via macropinocytosis; loss of VPS18 or VPS11 triggers the integrated stress response and turns off mTORC1. Du is the last author on the paper. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Xingrong Du.
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- Jing Wang Showed as first author that the CORVET/HOPS trafficking machinery is needed for T cells to sense amino acids and activate mTORC1
- Linling He Researcher in the Fudan team studying amino-acid sensing and stress resilience in T cells
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