Jing Wang
Showed as first author that the CORVET/HOPS trafficking machinery is needed for T cells to sense amino acids and activate mTORC1
Institute of Metabolism and Integrative Biology, Shanghai Key Laboratory of Metabolic Remodeling and Health · Fudan University, China
Institute of Metabolism and Integrative Biology, Fudan University (Shanghai, China) ↗
Jing Wang is first author of a 2026 PNAS paper from Fudan University's Institute of Metabolism and Integrative Biology (corresponding authors Tong-Jin Zhao and Xingrong Du). The study identifies the CORVET/HOPS membrane-tethering complexes as upstream gatekeepers of T-cell amino acid supply: they drive macropinocytosis to pull in extracellular nutrients, which dampens the cell's stress response and switches on mTORC1 signaling needed for T cells to proliferate and fight infection.
Deleting core CORVET/HOPS subunits starved T cells of amino acids, triggered a pathological stress response, blunted mTORC1 activity, and crippled immune responses in mice.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | M | Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells WANG2026 First author showing that CORVET/HOPS tethering complexes are required for T cells to import amino acids and activate mTORC1, linking nutrient trafficking to immune-cell metabolic resilience. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Jing Wang.
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- Linling He Researcher in the Fudan team studying amino-acid sensing and stress resilience in T cells
- Xingrong Du Studies how cellular metabolism and signaling shape the function of T cells, regulatory T cells and dendritic cells in tumor immunity, autoimmunity and immunodeficiency.
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