Stacey Robida-Stubbs
Researcher in Keith Blackwell's worm lab at the Joslin Diabetes Center who showed that TOR inhibition and rapamycin extend C. elegans lifespan through the protective factors SKN-1/Nrf and DAF-16/FoxO
Joslin Diabetes Center, Harvard Stem Cell Institute and Department of Genetics, Harvard Medical School (T. Keith Blackwell group, papers 2012–2022)
Stacey Robida-Stubbs is first author of an Atlas study (ROB2012) on how blocking TOR lengthens life in the roundworm C. elegans. Lowering TORC1 genetically extended lifespan, and that needed two transcription factors that switch on defence genes: SKN-1, the worm version of Nrf, which protects against oxidative and chemical stress, and DAF-16, the worm FoxO. Rapamycin also extended lifespan, but needed only SKN-1, not DAF-16. The authors traced this difference to rapamycin also acting on TORC2. They also saw that rapamycin switched on a similar Nrf-type protective response in mice.
The paper showed that turning down TOR does more than slow growth: it actively switches on the cell's protective programmes. It also gave an early warning that rapamycin does not act like a pure TORC1 blocker, a theme the Atlas follows into mice and people.
The publication record places Robida-Stubbs in T. Keith Blackwell's group at the Joslin Diabetes Center and Harvard Medical School from 2012 to at least 2022, including a 2022 Nature Communications paper showing that the stress factor ATF-4 and hydrogen sulfide production help explain why lowering protein synthesis or mTORC1 extends worm lifespan. No profile page was found, so the current role is not confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | A | TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO ROB2012 First author: showed in C. elegans that TORC1 inhibition extends lifespan through SKN-1/Nrf and DAF-16/FoxO, while rapamycin's effect needs only SKN-1. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Stacey Robida-Stubbs.
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- David M. Sabatini Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Dudley W. Lamming Showed as a postdoc that rapamycin's harm to glucose metabolism comes largely from its effect on mTORC2, while the lifespan benefit tracks mTORC1. His Wisconsin lab studies intermittent rapamycin dosing and how restricting dietary protein or single amino acids affects metabolism and ageing
- T. Keith Blackwell Geneticist who uses the worm C. elegans to study how the SKN-1/Nrf stress-response factor, insulin signaling and TOR shape stress resistance and lifespan.
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