Shinsuke Uda
Systems biologist who uses information theory and modelling. He co-authored the studies showing that the insulin–AKT pathway encodes insulin’s timing pattern, and that S6K, downstream of mTORC1, reads only the fast, pulse-like part.
Associate Professor, Information and Data Science Education Center, Yamaguchi University (since 2024) · Associate Professor, Integrated Omics, Medical Institute of Bioregulation, Kyushu University (2014–2022) · Assistant Professor, Graduate School of Science, University of Tokyo (2013) · PhD (Science), Tokyo Institute of Technology
Portrait: Yamaguchi University
Shinsuke Uda is a co-author on the cell study showing that pulse and sustained insulin produce transient and sustained AKT phosphorylation, and that S6K, G6Pase and GSK3-beta each read a different part of that signal (KUB2012). He then co-authored the in vivo follow-up in rat liver, where insulin clamps and mathematical modelling showed the same selective decoding and linked it to network structure and time constants (KUB2018).
His background is in communication engineering, information statistical mechanics and machine learning, which he applies to systems biology and trans-omics. He was an associate professor in Kyushu University’s Integrated Omics division from 2014 and moved to Yamaguchi University’s Information and Data Science Education Center in January 2024.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | Temporal coding of insulin action through multiplexing of the AKT pathway KUB2012 Co-author: AKT multiplexes insulin patterns in time; S6K decodes only the transient, pulse-like component. |
| 2018 | A | In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver KUB2018 Co-author (second author): in rat liver, downstream molecules decode blood insulin patterns through AKT, explained with mathematical modelling. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Shinsuke Uda.
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- Hiroyuki Kubota 2 shared studies Systems biologist who showed that the insulin pathway carries different messages in the timing of its signal, and that S6K, the mTORC1 target, reads only the fast part
- Shinya Kuroda 2 shared studies Leads a systems biology lab that studies how cells decode the timing of hormone signals, with insulin and mTORC1-S6K as the main test case
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