Randy J. Seeley
Studies how gut and brain signals control appetite, body weight and blood sugar, including why bariatric surgery works; his Cincinnati lab was senior on the rat study linking hypothalamic mTOR to food intake.
Henry King Ransom Endowed Professor of Surgery, University of Michigan (since 2014) · previously Professor of Medicine and Donald C. Harrison Endowed Chair, and Director of the Cincinnati Diabetes and Obesity Center, University of Cincinnati (from 1997) · postdoc, University of Washington (1993–1995) · PhD in psychology, University of Pennsylvania (1993)
Randy Seeley was senior author of the 2006 Science study led by Daniela Cota (COT2006). In rats, hypothalamic mTOR signalling changed with energy status, central leucine raised it and reduced food intake and body weight, and inhibiting mTOR with rapamycin blunted the appetite-lowering effect of leptin. The work suggested that hypothalamic mTOR acts as a nutrient sensor that feeds into the control of eating, in rats.
Seeley trained in psychology at Grinnell College and the University of Pennsylvania and did a postdoc at the University of Washington. He spent about 17 years at the University of Cincinnati, where he directed the Cincinnati Diabetes and Obesity Center, and moved to the University of Michigan in 2014. His lab studies gut-brain signalling, bariatric surgery and metabolism, including hormones such as GLP-1 and leptin and the bile-acid receptor FXR.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2006 | A | Hypothalamic mTOR signaling regulates food intake COT2006 Senior author: hypothalamic mTOR signalling responds to energy status and leucine, and is needed for leptin's full effect on food intake in rats. |
Co-authors in the Atlas
People with a profile here who share at least one study with Randy J. Seeley.
- Daniela Cota Studies how the brain senses nutrients and hormones to control food intake and body weight; as a postdoc in Cincinnati she was first author of the rat study that tied hypothalamic mTOR signalling to food intake and leptin action.
- George Thomas Purified and cloned S6K1, the kinase that became the classic readout of mTORC1 activity. His lab later showed that mice lacking S6K1 resist diet-induced obesity, and that amino acids signal to mTORC1 through the lipid kinase hVps34 (GUL2008)
- Sara C. Kozma Studies the S6K/mTOR pathway and how it controls cell growth, ribosome production, diabetes and cancer, including mTOR signalling in liver cancer.
Every researcher with a profile →
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