Patrick B. Dennis

As a postdoc in George Thomas's lab at the Friedrich Miescher Institute, was first author on the 2001 study proposing that mTOR responds to cellular ATP levels independently of amino acids

Research biochemist, Air Force Research Laboratory (protein-based biomaterials) · postdoc with George Thomas, Friedrich Miescher Institute, Basel (1993–2001) · PhD, University of North Texas (1993)

Lab lineagetrained under George Thomas →

Portrait: Materials Research Society (speaker profile)

Patrick Dennis was first author of the Atlas study reporting that lowering intracellular ATP reduces signalling through the mTOR pathway even when amino acids are present, and proposing that mTOR itself acts as an ATP sensor (DEN2001). Later work showed that much of the energy signal reaches mTORC1 through AMPK and TSC2, so the direct ATP-sensor idea became one part of a larger picture.

Dennis earned his PhD at the University of North Texas working on human protein kinases, then spent eight years in George Thomas's group at the Friedrich Miescher Institute in Basel studying how signalling controls protein synthesis. He later moved to the Air Force Research Laboratory at Wright-Patterson Air Force Base, where he works on protein-based biomaterials.

Milestones in the Atlas

A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.

Co-authors in the Atlas

People with a profile here who share at least one study with Patrick B. Dennis.

• George Thomas Purified and cloned S6K1, the kinase that became the classic readout of mTORC1 activity. His lab later showed that mice lacking S6K1 resist diet-induced obesity, and that amino acids signal to mTORC1 through the lipid kinase hVps34 (GUL2008)
• Sara C. Kozma Studies the S6K/mTOR pathway and how it controls cell growth, ribosome production, diabetes and cancer, including mTOR signalling in liver cancer.

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