Parveez Ahamed Abdul-Azees
Oral biology researcher at the UT Health San Antonio School of Dentistry who works on dental caries, oral biofilms and salivary gland ageing, and first author of the marmoset study of rapamycin and the ageing salivary gland
Center for Regenerative Sciences and Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio (papers 2023–2026)
Older people often have a dry mouth because their salivary glands shrink and scar. In the Atlas study ABD2026, Abdul-Azees, Chih-Ko Yeh and colleagues looked at the submandibular salivary gland of the common marmoset, a small primate that ages much faster than humans. Older glands had fewer of the cells that make saliva, more duct and scar-like connective tissue, more fat build-up and more dying and senescent (permanently arrested) cells. Marmosets given rapamycin by mouth for a long period kept more of the saliva-making structure and showed less scarring and fat build-up.
Rapamycin blocks mTORC1, the growth-control complex. The study suggests that some age-related damage in a primate gland can be slowed by this drug. It was a tissue study in a small number of animals and was not tested in people.
On PubMed, Abdul-Azees first appears in 2023 in Bennett Amaechi's group in the Department of Comprehensive Dentistry at UT Health San Antonio, on a laboratory model of tooth decay (an artificial mouth) and later on toothpaste formulas that prevent caries. Since 2025 the papers carry the Center for Regenerative Sciences affiliation with Chih-Ko Yeh and Xiao-Dong Chen, including work on how bacterial biofilms grow on dental filling materials.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | A | Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging. ABD2026 First author: described how the marmoset salivary gland changes with age and found partial preservation of gland structure with long-term oral rapamycin. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Parveez Ahamed Abdul-Azees.
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- Adam B. Salmon Biologist of aging at UT Health San Antonio whose work in this Atlas spans rapamycin in mice and in common marmosets. He is a co-author on the Interventions Testing Program reports from the San Antonio site and on the marmoset rapamycin studies on blood markers, epigenetic age and the salivary gland
- Chih-Ko Yeh Professor of Comprehensive Dentistry at UT Health San Antonio who studies how ageing changes saliva and the salivary glands, and how damaged glands might be repaired
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