Natalia Podlutskaya
Contributed, at the Barshop Institute in San Antonio, to mouse studies showing that rapamycin prevents Alzheimer's-like memory loss and improves cognition in normal ageing
Research advisor/mentor, BLaST Program, Univ. of Alaska Fairbanks (since 2015) · researcher, Barshop Institute, UT Health San Antonio (Richardson/Galvan labs, c. 2008–2013) · MS Biology, Kharkov University, Ukraine
BLaST Program, University of Alaska Fairbanks (Fairbanks, Alaska, USA) ↗
Portrait: University of Alaska Fairbanks (BLaST)
Contributed to SPI2010: long-term rapamycin prevented memory deficits and lowered amyloid-beta in an Alzheimer's mouse model, tracking with increased autophagy. Contributed to HAL2012: a lifespan-extending rapamycin dose improved learning/memory, reduced anxiety/depression-like behavior in mice.
Part of the broader Barshop Institute comparative-aging tradition (oxidative stress, mitochondrial function across long-lived mammals).
Moved into science education/mentoring at UAF's BLaST program, training undergraduates in molecular biology.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2010 | A | Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease SPI2010 Contributed to showing long-term rapamycin prevents memory deficits and lowers amyloid-beta in an Alzheimer's model. |
| 2012 | A | Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. HAL2012 Contributed to showing a lifespan-extending rapamycin dose improves cognition and reduces anxiety/depression-like behavior. |
Co-authors in the Atlas 7
People with a profile here who share at least one study with Natalia Podlutskaya.
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- Arlan Richardson 2 shared studies Studies how rapamycin slows ageing in mice, including the broad changes it causes in the liver, and co-authored early studies showing that rapamycin protects memory in Alzheimer's-model mice
- Randy Strong 2 shared studies Leads the San Antonio site of the NIA Interventions Testing Program, which tests each compound in parallel at three sites under one shared protocol. He first-authored the program's reports on resveratrol and other supplements (2012) and on rapamycin combined with acarbose (2022)
- Veronica Galvan 2 shared studies Led mouse studies showing that rapamycin prevents Alzheimer's-like memory loss and amyloid build-up, and improves learning in normally ageing mice
- Jayanta Debnath Physician-scientist who studies how autophagy - the cell's self-digestion system - keeps epithelial tissue healthy and how tumours hijack it
- Jonathan J. Halloran First author of a 2012 mouse study showing that lifelong rapamycin does not cost the brain anything and even protects learning and memory with age; long-time member of Veronica Galvan's aging and Alzheimer's research group in San Antonio
- Patricia Spilman Neuroscientist who showed, with Veronica Galvan, that long-term rapamycin prevents memory loss in an Alzheimer's mouse model, and who later worked with Dale Bredesen on Alzheimer's drug discovery
- Stacy A. Hussong Studies how mTOR damages the brain's blood vessels, and how blocking it restores blood flow, the blood-brain barrier and memory in aging and Alzheimer's models
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